P21917 | DRD4_HUMAN | D(4) dopamine receptor (DRD4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 51~400 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL93403 |  |
IC50 | = | 0.057 | nM | 373.88 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL267930 |  |
IC50 | = | 0.5 | nM | 395.48 | O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL2395272 | cell-based format |
| CHEMBL127290 |  |
IC50 | = | 1.0 | nM | 320.44 | Cc1ccc(C)c(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | Homo sapiens | CHEMBL670988 | cell-based format |
| CHEMBL286725 |  |
IC50 | = | 1.0 | nM | 369.46 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL555670 |  |
IC50 | = | 1.0 | nM | 363.29 | Cl.Clc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL147483 |  |
IC50 | = | 1.0 | nM | 340.43 | COc1cccc(C(=O)NCCN2CCN(c3ccccn3)CC2)c1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL69584 |  |
IC50 | = | 1.6 | nM | 369.9 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | Homo sapiens | CHEMBL872218 | single protein format |
| CHEMBL320597 |  |
IC50 | = | 2.0 | nM | 363.5 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | Homo sapiens | CHEMBL872218 | single protein format |
| CHEMBL59942 |  |
IC50 | = | 2.0 | nM | 348.43 | Fc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL357448 |  |
IC50 | = | 2.8 | nM | 383.49 | COc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL107742 |  |
IC50 | = | 3.0 | nM | 363.5 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | Homo sapiens | CHEMBL872218 | single protein format |
| CHEMBL1202216 |  |
IC50 | = | 3.0 | nM | 403.36 | Br.COc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | Homo sapiens | CHEMBL676183 | single protein format |
| CHEMBL64597 |  |
IC50 | = | 3.0 | nM | 336.46 | c1cnc(N2CCN(Cc3cccc(-c4ccsc4)c3)CC2)nc1 | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL61682 |  |
IC50 | = | 3.0 | nM | 365.43 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4F)CC3)c2)cc1 | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL1202211 |  |
IC50 | = | 3.0 | nM | 437.81 | Br.COc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | Homo sapiens | CHEMBL676183 | single protein format |
| CHEMBL26677 |  |
IC50 | = | 3.1 | nM | 368.48 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL62829 |  |
IC50 | = | 4.0 | nM | 348.42 | Fc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL356358 |  |
IC50 | = | 4.0 | nM | 369.46 | COc1ccccc1C(=O)NCCN1CCN(c2ccccc2OC)CC1 | Homo sapiens | CHEMBL676184 | single protein format |
| CHEMBL64119 |  |
IC50 | = | 5.0 | nM | 455.56 | CC(C)Oc1cccnc1N(C)C1CCN(Cc2ccccc2)CC1.O=C(O)/C=C\C(=O)O | Homo sapiens | CHEMBL676182 | cell-based format |
| CHEMBL127257 |  |
IC50 | = | 5.0 | nM | 320.44 | Cc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1C | Homo sapiens | CHEMBL670988 | cell-based format |