P21860 | ERBB3_HUMAN | Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00757 | Furin-like - Furin-like cysteine rich region | 182~332 | |
| PF01030 | Recep_L_domain - Receptor L domain | 56~166 | |
| PF01030 | Recep_L_domain - Receptor L domain | 353~472 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 711~964 | |
| PF14843 | GF_recep_IV - Growth factor receptor domain IV | 499~629 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Growth factor receptor domain" // GF_recep_IV ]
[ Domain: "Growth factor receptor domain" // Furin-like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3883534 |  |
IC50 | = | 1.0 | nM | 372.79 | C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL4228518 |  |
IC50 | = | 1.2 | nM | 508.62 | CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccc(F)cc4)n(C4CCOCC4)c3n2)cc1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4225777 |  |
IC50 | = | 1.7 | nM | 490.63 | CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4226676 |  |
IC50 | = | 1.9 | nM | 529.71 | CN(C)C1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCOCC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL3608429 |  |
IC50 | = | 2.0 | nM | 413.46 | C=CC(=O)N[C@@H]1CN(c2nc(Nc3cnn(C)c3)c3ncn(C(C)C)c3n2)C[C@H]1F | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL4226151 |  |
IC50 | = | 2.0 | nM | 501.66 | CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCOCC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4216679 |  |
IC50 | = | 2.0 | nM | 443.49 | C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3OC)c3ncn(C(C)C)c3n2)C[C@H]1F | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL3353410 |  |
IC50 | = | 2.1 | nM | 499.62 | C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4225565 |  |
IC50 | = | 2.4 | nM | 515.69 | CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n([C@H]5CC[C@H](O)CC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4227084 |  |
IC50 | = | 2.6 | nM | 506.63 | CN(C)CCOc1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCOCC4)c3n2)cc1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL2408045 |  |
IC50 | = | 4.0 | nM | 473.94 | CNC(=O)CN1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1 | Homo sapiens | CHEMBL2412603 | cell-based format |
| CHEMBL3989970 |  |
IC50 | = | 4.0 | nM | 415.43 | C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3OC)c3ncn(C)c3n2)C[C@H]1F | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL4225951 |  |
IC50 | = | 4.2 | nM | 501.66 | CN1CCN(c2ccc(Nc3ncc4nc([S+]([O-])c5ccccc5)n(C5CCCC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4225306 |  |
IC50 | = | 4.2 | nM | 485.66 | CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL4226937 |  |
IC50 | = | 5.8 | nM | 508.62 | CN(C)CCOc1ccc(Nc2ncc3nc(Sc4cccc(F)c4)n(C4CCOCC4)c3n2)cc1 | Homo sapiens | CHEMBL4222845 | single protein format |
| CHEMBL3608432 |  |
IC50 | = | 9.0 | nM | 427.49 | C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3C)c3ncn(C(C)C)c3n2)C[C@H]1F | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL553 |  |
IC50 | = | 10.0 | nM | 393.44 | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 | Homo sapiens | CHEMBL4178362 | cell-based format |
| CHEMBL4288300 |  |
IC50 | = | 18.0 | nM | 352.39 | COc1cccc(Nc2cc(Nc3cc(OC)ccc3OC)ncn2)c1 | Homo sapiens | CHEMBL4267259 | assay format |
| CHEMBL4282460 |  |
IC50 | = | 21.0 | nM | 334.76 | O=C(O)CCCC(=O)Nc1cc(Nc2cccc(Cl)c2)ncn1 | Homo sapiens | CHEMBL4267259 | assay format |
| CHEMBL3786098 |  |
IC50 | = | 21.0 | nM | 431.88 | C=CC(=O)N1C[C@H](COc2nc(Nc3cnn(C)c3)nc3[nH]cc(Cl)c23)[C@@H](OC)C1 | Homo sapiens | CHEMBL4178362 | cell-based format |