P21817 | RYR1_HUMAN | Ryanodine receptor 1 (RYR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 4767~4948 | |
| PF00622 | SPRY - SPRY domain | 660~794 | |
| PF00622 | SPRY - SPRY domain | 1086~1205 | |
| PF00622 | SPRY - SPRY domain | 1432~1568 | |
| PF01365 | RYDR_ITPR - RIH domain | 443~636 | |
| PF01365 | RYDR_ITPR - RIH domain | 2160~2368 | |
| PF02026 | RyR - RyR domain | 850~939 | |
| PF02026 | RyR - RyR domain | 964~1053 | |
| PF02026 | RyR - RyR domain | 2735~2825 | |
| PF02026 | RyR - RyR domain | 2855~2939 | |
| PF02815 | MIR - MIR domain | 211~389 | |
| PF06459 | RR_TM4-6 - Ryanodine Receptor TM 4-6 | 4383~4671 | |
| PF08454 | RIH_assoc - RyR and IP3R Homology associated | 3876~3991 | |
| PF08709 | Ins145_P3_rec - Inositol 1,4,5-trisphosphate/ryanodine receptor | 9~209 | |
| PF21119 | RYDR_Jsol - Ryanodine receptor junctional solenoid repeat | 1662~2126 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL308183 |  |
IC50 | = | 3.5 | nM | 493.55 | CC1CCC2(O)C3(C)CC4(O)OC2(C1O)C1(O)C3(O)C(OC(=O)c2ccc[nH]2)C(O)(C(C)C)C41C | Homo sapiens | CHEMBL873120 | single protein format |
| CHEMBL308183 | |
Ki | = | 1.8 | nM | 493.55 | CC1CCC2(O)C3(C)CC4(O)OC2(C1O)C1(O)C3(O)C(OC(=O)c2ccc[nH]2)C(O)(C(C)C)C41C | Homo sapiens | CHEMBL803054 | cell membrane format |