P21817 | RYR1_HUMAN | Ryanodine receptor 1 (RYR1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans | 4767–4948 | |
| PF00622 | SPRY | 660–794 | |
| PF00622 | SPRY | 1086–1205 | |
| PF00622 | SPRY | 1432–1568 | |
| PF01365 | RYDR_ITPR | 443–636 | |
| PF01365 | RYDR_ITPR | 2160–2368 | |
| PF02026 | RyR | 850–939 | |
| PF02026 | RyR | 964–1053 | |
| PF02026 | RyR | 2735–2825 | |
| PF02026 | RyR | 2855–2939 | |
| PF02815 | MIR | 211–389 | |
| PF06459 | RR_TM4-6 | 4383–4671 | |
| PF08454 | RIH_assoc | 3876–3991 | |
| PF08709 | Ins145_P3_rec | 9–209 | |
| PF21119 | RYDR_Jsol | 1662–2126 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL308183 |  |
IC50 | = | 3.5 | nM | 493.55 | CC1CCC2(O)C3(C)CC4(O)OC2(C1O)C1(O)C3(O)C(OC(=O)c2ccc[nH]2)C(O)(C(C)C)C41C | Homo sapiens | CHEMBL873120 | single protein format |
| CHEMBL308183 | |
Ki | = | 1.8 | nM | 493.55 | CC1CCC2(O)C3(C)CC4(O)OC2(C1O)C1(O)C3(O)C(OC(=O)c2ccc[nH]2)C(O)(C(C)C)C41C | Homo sapiens | CHEMBL803054 | cell membrane format |