P21731 | TA2R_HUMAN | Thromboxane A2 receptor (TBXA2R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 42~308 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL435382 |  |
IC50 | = | 0.13 | nM | 427.57 | O=C(O)CCC/C=C\C[C@H]1[C@@H]2CC[C@@H](C2)[C@@H]1NS(=O)(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL811626 | assay format |
| CHEMBL209168 |  |
IC50 | = | 0.46 | nM | 418.48 | Cc1ccc(Nc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)N2CCCCC2)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL379736 |  |
IC50 | = | 0.71 | nM | 426.54 | CCCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1NC1CCCCC1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL208818 |  |
IC50 | = | 0.72 | nM | 435.5 | CCCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Oc1ccc(C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL209406 |  |
IC50 | = | 0.74 | nM | 407.45 | CCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Oc1ccc(C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL380274 |  |
IC50 | = | 0.77 | nM | 423.52 | Cc1ccc(Sc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL209306 |  |
IC50 | = | 0.78 | nM | 420.49 | Cc1cccc(C)c1Nc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC(=O)NC(C)(C)C | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL208115 |  |
IC50 | = | 1.01 | nM | 420.49 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Nc1cccc(C)c1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL210602 |  |
IC50 | = | 1.05 | nM | 406.46 | Cc1ccc(Nc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL379659 |  |
IC50 | = | 1.08 | nM | 434.52 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Nc1cc(C)cc(C)c1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL7353 |  |
IC50 | = | 1.1 | nM | 412.51 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1NC1CCCCC1 | Homo sapiens | CHEMBL811637 | single protein format |
| CHEMBL209035 |  |
IC50 | = | 1.26 | nM | 407.45 | Cc1ccc(Oc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL377679 |  |
IC50 | = | 1.52 | nM | 434.52 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Nc1c(C)cccc1C | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL208543 |  |
IC50 | = | 1.52 | nM | 433.49 | Cc1ccc(Oc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL209134 |  |
IC50 | = | 1.82 | nM | 499.39 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Nc1ccc(Br)c(C)c1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL209245 |  |
IC50 | = | 1.9 | nM | 440.48 | Cc1ccc(Nc2ccc([N+](=O)[O-])cc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL211008 |  |
IC50 | = | 2.5 | nM | 440.57 | CCCCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1NC1CCCCC1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL274415 |  |
IC50 | = | 2.63 | nM | 421.48 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Oc1ccc(C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL210964 |  |
IC50 | = | 2.65 | nM | 420.49 | CCCCCNC(=O)NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Nc1ccc(C)cc1 | Homo sapiens | CHEMBL863214 | cell-based format |
| CHEMBL420002 |  |
IC50 | = | 4.4 | nM | 386.46 | Cc1c(C)c(C=O)c(C)c(C(CCCCCC(=O)O)c2ccc(F)cc2)c1O | Homo sapiens | CHEMBL815552 | cell membrane format |