P21730 | C5AR1_HUMAN | C5a anaphylatoxin chemotactic receptor 1 (C5AR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 54~300 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Domain: "Cytochromes" // Cytochrom_B562_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL486749 |  |
IC50 | = | 1.5 | nM | 456.03 | CC(C)Cc1ccccc1C(=O)N(CCc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL465377 |  |
IC50 | = | 3.0 | nM | 522.04 | CCOC(=O)C(Cc1ccc(Cl)cc1)N(C(=O)c1cccc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL471017 |  |
IC50 | = | 5.0 | nM | 528.07 | CCOC(=O)C(Cc1ccc(Cl)cc1)N(C(=O)c1csc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL520715 |  |
IC50 | = | 5.0 | nM | 454.04 | O=C(c1csc2ccccc12)N(CCc1ccc(Cl)cc1)[C@H]1CC[C@]2(CCCO2)CC1 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL513964 |  |
IC50 | = | 8.0 | nM | 510.03 | CCc1ccccc1C(=O)N(C1CCC2(CC1)OCCO2)C(Cc1ccc(Cl)cc1)c1noc(C)n1 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL513344 |  |
IC50 | = | 12.0 | nM | 500.06 | COCC(Cc1ccc(Cl)cc1)N(C(=O)c1csc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL468430 |  |
IC50 | = | 13.0 | nM | 507.07 | CN(C)CC(Cc1ccc(Cl)cc1)N(C(=O)c1cccc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL514872 |  |
IC50 | = | 15.0 | nM | 514.04 | COC(=O)C(Cc1ccc(Cl)cc1)N(C(=O)c1csc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL486953 |  |
IC50 | = | 18.0 | nM | 427.97 | CCc1ccccc1C(=O)N(CCc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL68555 |  |
IC50 | = | 25.0 | nM | 522.69 | N=C(N)NCCC[C@H]1NC(=O)N([C@H](CC2CCCCC2)C(=O)N2CCC3(CCc4ccccc43)CC2)C1=O | Homo sapiens | CHEMBL652979 | assay format |
| CHEMBL467571 |  |
IC50 | = | 27.0 | nM | 485.07 | CCc1ccccc1C(=O)N(C1CCC2(CC1)OCCO2)C(Cc1ccc(Cl)cc1)CN(C)C | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL308932 |  |
IC50 | = | 30.0 | nM | 496.66 | N=C(N)NCCC[C@H]1NC(=O)N([C@H](CC2CCCCC2)C(=O)N2CCC(c3ccccc3)CC2)C1=O | Homo sapiens | CHEMBL652979 | assay format |
| CHEMBL463115 |  |
IC50 | = | 31.0 | nM | 554.06 | O=C(Nc1ccc(F)cc1F)N1CCC(N(CCc2ccc(Cl)cc2)C(=O)c2csc3ccccc23)CC1 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL471210 |  |
IC50 | = | 35.0 | nM | 470.03 | CC(CN(C(=O)c1csc2ccccc12)C1CCC2(CC1)OCCO2)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1008821 | cell-based format |
| CHEMBL420736 |  |
IC50 | = | 40.0 | nM | 511.67 | Cc1ccccc1N1CCN(C(=O)[C@@H](CC2CCCCC2)N2C(=O)N[C@H](CCCN=C(N)N)C2=O)CC1 | Homo sapiens | CHEMBL652979 | assay format |
| CHEMBL302063 |  |
IC50 | = | 40.0 | nM | 525.7 | Cc1cccc(C)c1N1CCN(C(=O)[C@@H](CC2CCCCC2)N2C(=O)N[C@H](CCCN=C(N)N)C2=O)CC1 | Homo sapiens | CHEMBL652979 | assay format |
| CHEMBL468429 |  |
IC50 | = | 45.0 | nM | 498.04 | CC(=O)C(Cc1ccc(Cl)cc1)N(C(=O)c1csc2ccccc12)C1CCC2(CC1)OCCO2 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL457790 |  |
IC50 | = | 47.0 | nM | 436.62 | c1ccc2c(-c3ncc(CC4CCCCC4)n3C3CCC4(CC3)OCCO4)csc2c1 | Homo sapiens | CHEMBL1019502 | cell-based format |
| CHEMBL431761 |  |
IC50 | = | 60.0 | nM | 525.7 | Cc1ccc(N2CCN(C(=O)[C@@H](CC3CCCCC3)N3C(=O)N[C@H](CCCN=C(N)N)C3=O)CC2)c(C)c1 | Homo sapiens | CHEMBL652979 | assay format |
| CHEMBL487167 |  |
IC50 | = | 70.0 | nM | 413.97 | O=C(c1csc2ccccc12)N(CCc1ccc(Cl)cc1)[C@H]1CC[C@H](O)CC1 | Homo sapiens | CHEMBL1008821 | cell-based format |