P21728 | DRD1_HUMAN | D(1A) dopamine receptor (DRD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 40~331 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 0.21 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121475 | single protein format |
| CHEMBL1814790 |  |
IC50 | = | 0.22 | nM | 403.86 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C=C\C(=O)O | Homo sapiens | CHEMBL2395589 | single protein format |
| CHEMBL13668 |  |
IC50 | = | 0.31 | nM | 287.79 | CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1 | Homo sapiens | CHEMBL3779712 | cell-based format |
| CHEMBL62 |  |
IC50 | = | 0.66 | nM | 287.79 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | Homo sapiens | CHEMBL881983 | single protein format |
| CHEMBL2057455 |  |
IC50 | = | 4.86 | nM | 341.41 | COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL3913343 |  |
IC50 | = | 7.22 | nM | 341.41 | COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL194837 |  |
IC50 | = | 7.5 | nM | 448.35 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | Homo sapiens | CHEMBL881881 | single protein format |
| CHEMBL2334893 |  |
IC50 | = | 8.19 | nM | 325.36 | COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL487387 |  |
IC50 | = | 12.29 | nM | 327.38 | COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL3917753 |  |
IC50 | = | 13.27 | nM | 327.38 | COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL2057445 |  |
IC50 | = | 14.29 | nM | 355.43 | COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL2334881 |  |
IC50 | = | 14.65 | nM | 339.39 | COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL726 |  |
IC50 | = | 23.0 | nM | 437.53 | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 | Homo sapiens | CHEMBL1909139 | cell membrane format |
| CHEMBL2057456 |  |
IC50 | = | 30.7 | nM | 371.43 | COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL1909072 |  |
IC50 | = | 32.0 | nM | 401.96 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909139 | cell membrane format |
| CHEMBL2057446 |  |
IC50 | = | 45.45 | nM | 385.46 | COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL3897805 |  |
IC50 | = | 47.9 | nM | 339.39 | COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL3986624 |  |
IC50 | = | 49.23 | nM | 353.42 | COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4 | Homo sapiens | CHEMBL3888597 | cell-based format |
| CHEMBL2057457 |  |
IC50 | = | 56.37 | nM | 309.41 | COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2 | Homo sapiens | CHEMBL2060920 | cell-based format |
| CHEMBL2057453 |  |
IC50 | = | 68.89 | nM | 311.38 | COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2 | Homo sapiens | CHEMBL2060920 | cell-based format |