P21709 | EPHA1_HUMAN | Ephrin type-A receptor 1 (EPHA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 334~431 | |
| PF00041 | fn3 - Fibronectin type III domain | 454~532 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 914~975 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 28~204 | |
| PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 275~309 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 626~880 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 548~621 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 205~264 |
3D structures mapped by conservation among orthologs
[ Domain: "SAM domain-like" // SAM_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL566515 |  |
IC50 | = | 2.9 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046770 | single protein format |
| CHEMBL3979920 |  |
IC50 | = | 31.0 | nM | 344.39 | Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 | Homo sapiens | CHEMBL3869728 | assay format |
| CHEMBL388978 |  |
IC50 | = | 49.8 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820482 | single protein format |
| CHEMBL1276179 |  |
IC50 | = | 95.3 | nM | 534.57 | CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 | Homo sapiens | CHEMBL1285875 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 143.0 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4721790 | single protein format |
| CHEMBL5425418 |  |
IC50 | = | 145.0 | nM | 359.38 | CNc1ncc2cc(-c3cc(F)ccc3F)c(=O)n(CCCCN)c2n1 | Homo sapiens | CHEMBL5327132 | cell-based format |
| CHEMBL5092606 |  |
IC50 | = | 303.35 | nM | 422.46 | CN(C)C(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1 | Homo sapiens | CHEMBL5045722 | single protein format |
| CHEMBL3752910 |  |
IC50 | = | 303.4 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212790 | assay format |
| CHEMBL5089164 |  |
IC50 | = | 392.9 | nM | 432.45 | Cn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O | Homo sapiens | CHEMBL5045722 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 630.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1932842 | single protein format |
| CHEMBL1923983 |  |
IC50 | = | 686.0 | nM | 379.42 | CNc1nc2[nH]c(-c3cccc(CNC(=O)COC)n3)cc2c2c1ncn2C | Homo sapiens | CHEMBL1924441 | single protein format |