P21675 | TAF1_HUMAN | Transcription initiation factor TFIID subunit 1 (TAF1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 1411~1491 | |
| PF00439 | Bromodomain - Bromodomain | 1537~1616 | |
| PF09247 | TBP-binding - TATA box-binding protein binding | 26~86 | |
| PF12157 | DUF3591 - Protein of unknown function (DUF3591) | 586~1048 | |
| PF15288 | zf-CCHC_6 - Zinc knuckle | 1282~1323 |
3D structures mapped by conservation among orthologs
[ Domain: "TFIID subunits TAF1-TAF7" // TAFII55_N ]
[ Domain: "TFIID subunits TAF1-TAF7" // DUF3591_1st ]
[ Domain: "winged" // DUF3591_2nd ]
[ Domain: "TAF(II)230 TBP-binding fragment" // TBP-binding ]
[ Domain: "Bromodomain" // Bromodomain ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4062266 |  |
IC50 | = | 3.0 | nM | 428.49 | CCCNc1ccc2c3c(cccc13)C(=O)N(c1cc3c(cc1C)n(C)c(=O)n3C)C2=O | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4086958 |  |
IC50 | = | 4.0 | nM | 450.29 | Cc1cc2c(cc1N1C(=O)c3cccc4c(Br)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4072812 |  |
IC50 | = | 4.0 | nM | 469.55 | Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCN(C)CC5)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4440829 |  |
IC50 | = | 4.0 | nM | 422.49 | C=CCCn1cc(-c2cnc(OCC)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4091912 |  |
IC50 | = | 6.0 | nM | 497.6 | Cc1cc2c(cc1N1C(=O)c3cccc4c(N(C)CCN5CCCC5)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4586175 |  |
IC50 | = | 6.0 | nM | 443.45 | C=CCCn1cc(-c2cc(OC(F)F)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4441257 |  |
IC50 | = | 6.0 | nM | 411.89 | C=CCCn1cc(-c2ccc(Cl)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4453202 |  |
IC50 | = | 6.0 | nM | 445.52 | C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3ncn(CC)c3c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4092917 |  |
IC50 | = | 7.0 | nM | 454.53 | Cc1cc2c(cc1N1C(=O)c3cccc4c(N5CCCCC5)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4059651 |  |
IC50 | = | 7.0 | nM | 443.5 | Cc1cc2c(cc1N1C(=O)c3cccc4c(CCCCO)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4566599 |  |
IC50 | = | 7.0 | nM | 408.46 | C=CCCn1cc(-c2cnc(OC)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4075478 |  |
IC50 | = | 8.0 | nM | 405.84 | Cc1cc2c(cc1N1C(=O)c3cccc4c(Cl)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4086276 |  |
IC50 | = | 8.0 | nM | 429.48 | Cc1cc2c(cc1N1C(=O)c3cccc4c(CCCO)ccc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |
| CHEMBL4455513 |  |
IC50 | = | 10.0 | nM | 431.5 | C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3c(c2)ncn3C)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4463538 |  |
IC50 | = | 10.0 | nM | 431.5 | C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)cc3c2ncn3C)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4520419 |  |
IC50 | = | 10.0 | nM | 395.43 | C=CCCn1cc(-c2ccc(F)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4483587 |  |
IC50 | < | 10.0 | nM | 522.65 | COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ccc2c(n1)N(C1CCOCC1)[C@H](C)C(=O)N2C | Homo sapiens | CHEMBL4308743 | assay format |
| CHEMBL4437997 |  |
IC50 | = | 11.0 | nM | 413.42 | C=CCCn1cc(-c2cc(F)c(F)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4459660 |  |
IC50 | = | 13.0 | nM | 392.46 | C=CCCn1cc(-c2cnc(C)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL4310221 | single protein format |
| CHEMBL4077317 |  |
IC50 | = | 13.0 | nM | 387.4 | Cc1cc2c(cc1N1C(=O)c3cccc4cc(O)cc(c34)C1=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051534 | assay format |