P21452 | NK2R_HUMAN | Substance-K receptor (TACR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 50~307 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL308148 |  |
IC50 | = | 0.13 | nM | 552.55 | CC(=O)NC1(c2ccccc2)CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | Homo sapiens | CHEMBL744866 | cell-based format |
| CHEMBL3642171 |  |
IC50 | = | 0.22 | nM | 536.93 | CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642170 |  |
IC50 | = | 0.22 | nM | 566.91 | CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642166 |  |
IC50 | = | 0.23 | nM | 584.47 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642168 |  |
IC50 | = | 0.25 | nM | 556.53 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642164 |  |
IC50 | = | 0.31 | nM | 550.91 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642157 |  |
IC50 | = | 0.45 | nM | 595.37 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL4111499 |  |
IC50 | = | 0.55 | nM | 290.75 | CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642165 |  |
IC50 | = | 0.56 | nM | 546.5 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642169 |  |
IC50 | = | 0.82 | nM | 596.35 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642160 |  |
IC50 | = | 1.1 | nM | 550.91 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL4128926 |  |
IC50 | = | 1.2 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121489 | single protein format |
| CHEMBL3642161 |  |
IC50 | = | 1.7 | nM | 592.57 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL3642159 |  |
IC50 | = | 2.0 | nM | 530.5 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL370013 |  |
IC50 | = | 2.25 | nM | 550.53 | NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 | Homo sapiens | CHEMBL882910 | single protein format |
| CHEMBL3642158 |  |
IC50 | = | 2.3 | nM | 546.5 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 | Homo sapiens | CHEMBL3708009 | cell-based format |
| CHEMBL166161 |  |
IC50 | = | 2.5 | nM | 414.55 | COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 | Homo sapiens | CHEMBL815378 | single protein format |
| CHEMBL26860 |  |
IC50 | = | 3.9 | nM | 577.6 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 | Homo sapiens | CHEMBL751788 | single protein format |
| CHEMBL519240 |  |
IC50 | = | 5.7 | nM | 327.43 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | Homo sapiens | CHEMBL947363 | single protein format |
| CHEMBL354422 |  |
IC50 | = | 6.0 | nM | 576.69 | CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 | Homo sapiens | CHEMBL815378 | single protein format |