P20839 | IMDH1_HUMAN | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00478 | IMPDH - IMP dehydrogenase / GMP reductase domain | 29~115 | |
| PF00478 | IMPDH - IMP dehydrogenase / GMP reductase domain | 164~175 | |
| PF00478 | IMPDH - IMP dehydrogenase / GMP reductase domain | 230~504 | |
| PF00571 | CBS - CBS domain | 116~163 | |
| PF00571 | CBS - CBS domain | 176~229 |
3D structures mapped by conservation among orthologs
[ Domain: "CBS-domain" // IMPDH_2nd ]
[ Domain: "TIM barrels" // IMPDH_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL208921 |  |
IC50 | = | 37.0 | nM | 383.38 | CCc1c(C)c2c(c(O)c1C/C=C(\C)CNCCP(=O)(O)O)C(=O)OC2 | Homo sapiens | CHEMBL865551 | single protein format |
| CHEMBL209069 |  |
IC50 | = | 38.0 | nM | 370.34 | CCc1c(C)c2c(c(O)c1C/C=C(\C)COCP(=O)(O)O)C(=O)OC2 | Homo sapiens | CHEMBL865551 | single protein format |
| CHEMBL152988 |  |
IC50 | = | 46.0 | nM | 332.36 | COc1cc2nc(-c3ccc(C)cc3)cc(O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL65013 |  |
IC50 | = | 55.0 | nM | 323.35 | COc1cc(NC(=O)Nc2cccc(C)c2)ccc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL347721 |  |
IC50 | = | 55.0 | nM | 324.36 | COc1cc2nc(-c3ccsc3)cc(O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL866 |  |
IC50 | = | 55.0 | nM | 320.34 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL428633 |  |
IC50 | = | 71.0 | nM | 340.31 | CCc1c(C)c2c(c(O)c1C/C=C(\C)CP(=O)(O)O)C(=O)OC2 | Homo sapiens | CHEMBL865551 | single protein format |
| CHEMBL358876 |  |
IC50 | = | 83.0 | nM | 346.39 | COc1cc2nc(-c3ccc(C)c(C)c3)cc(O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL152959 |  |
IC50 | = | 90.0 | nM | 348.36 | COc1ccc(-c2cc(O)c3cc(-c4cnco4)c(OC)cc3n2)cc1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL23843 |  |
IC50 | = | 99.0 | nM | 318.33 | COc1cc2nc(-c3ccccc3)cc(O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL2418580 |  |
IC50 | = | 105.0 | nM | 386.41 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)Nc1ncn[nH]1)C(=O)OC2 | Homo sapiens | CHEMBL2422864 | single protein format |
| CHEMBL150777 |  |
IC50 | = | 150.0 | nM | 332.36 | COc1cc2nc(-c3cccc(C)c3)cc(O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL698514 | single protein format |
| CHEMBL132727 |  |
IC50 | = | 150.0 | nM | 306.31 | C/C(=C\Cc1c(O)c(C)c2c(c1O)C(=O)OC2)CCC(=O)O | Homo sapiens | CHEMBL1292995 | assay format |
| CHEMBL23716 |  |
IC50 | = | 160.0 | nM | 374.42 | COc1cc2[nH]c(-c3csc4ccccc34)c(C=O)c2cc1-c1cnco1 | Homo sapiens | CHEMBL615265 | single protein format |
| CHEMBL238461 |  |
IC50 | = | 350.0 | nM | 335.36 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)NO)C(=O)OC2 | Homo sapiens | CHEMBL1292995 | assay format |
| CHEMBL2418585 |  |
IC50 | = | 558.0 | nM | 361.39 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@@H]1CO1)C(=O)OC2 | Homo sapiens | CHEMBL2422864 | single protein format |
| CHEMBL2418586 |  |
IC50 | = | 680.0 | nM | 361.39 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H]1CO1)C(=O)OC2 | Homo sapiens | CHEMBL2422864 | single protein format |
| CHEMBL157617 |  |
IC50 | = | 770.0 | nM | 306.36 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCCO)C(=O)OC2 | Homo sapiens | CHEMBL1292995 | assay format |
| CHEMBL424363 |  |
IC50 | = | 940.0 | nM | 308.33 | COc1c(C)c2c(c(O)c1CCCCCC(=O)O)C(=O)OC2 | Homo sapiens | CHEMBL697169 | single protein format |
| CHEMBL3098168 |  |
Ki | = | 32.0 | nM | 506.56 | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)O)C(=O)OC2 | Homo sapiens | CHEMBL3101581 | single protein format |