P20701 | ITAL_HUMAN | Integrin alpha-L (ITGAL)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00092 | VWA - von Willebrand factor type A domain | 156~325 | |
| PF00357 | Integrin_alpha - Integrin alpha cytoplasmic region | 1113~1127 | |
| PF01839 | FG-GAP - FG-GAP repeat | 460~497 | |
| PF01839 | FG-GAP - FG-GAP repeat | 521~554 | |
| PF08441 | Integrin_A_Ig_1 - Integrin alpha Ig-like domain 1 | 612~757 | |
| PF20805 | Integrin_A_Ig_2 - Integrin alpha Ig-like domain 2 | 771~917 |
3D structures mapped by conservation among orthologs
[ Domain: "7-bladed" // FG-GAP_1st ]
[ Domain: "Integrin alpha-L cytoplasmic domain" // Integrin_alpha ]
[ Domain: "vWA-like" // VWA ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1221918 |  |
IC50 | = | 1.4 | nM | 537.42 | O=C(NC[C@H](NC(=O)c1c(Cl)cc(CCC(O)c2cccc(O)c2)cc1Cl)C(=O)O)c1cccs1 | Homo sapiens | CHEMBL1227566 | single protein format |
| CHEMBL1094128 |  |
IC50 | = | 1.8 | nM | 592.46 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3s1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1098727 |  |
IC50 | = | 1.8 | nM | 560.41 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(-c3nnn[nH]3)cn1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1098726 |  |
IC50 | = | 2.5 | nM | 536.38 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL337562 |  |
IC50 | = | 3.0 | nM | 561.5 | O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2C(F)(F)F)CC1 | Homo sapiens | CHEMBL699110 | single protein format |
| CHEMBL1094115 |  |
IC50 | = | 3.6 | nM | 536.38 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ccn1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1094127 |  |
IC50 | = | 4.0 | nM | 576.4 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cc(C(=O)O)ccc3o1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1098437 |  |
IC50 | = | 4.4 | nM | 592.46 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3s1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1095138 |  |
IC50 | = | 4.8 | nM | 576.4 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3o1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL1096088 |  |
IC50 | = | 5.0 | nM | 542.4 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ncc(C(=O)O)s1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL139349 |  |
IC50 | = | 5.0 | nM | 527.95 | O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2C(F)(F)F)CC1 | Homo sapiens | CHEMBL698471 | single protein format |
| CHEMBL336789 |  |
IC50 | = | 5.0 | nM | 533.49 | COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1C(F)(F)F | Homo sapiens | CHEMBL872962 | single protein format |
| CHEMBL343390 |  |
IC50 | = | 5.0 | nM | 556.53 | Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(C(F)(F)F)c3C(F)(F)F)ccc21 | Homo sapiens | CHEMBL699115 | single protein format |
| CHEMBL138185 |  |
IC50 | = | 6.0 | nM | 489.42 | Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(Cl)c3Cl)ccc21 | Homo sapiens | CHEMBL698476 | single protein format |
| CHEMBL139068 |  |
IC50 | = | 6.0 | nM | 499.94 | COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL698472 | single protein format |
| CHEMBL1095148 |  |
IC50 | = | 6.0 | nM | 576.4 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3o1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL341999 |  |
IC50 | = | 7.0 | nM | 493.41 | CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 | Homo sapiens | CHEMBL699118 | single protein format |
| CHEMBL139390 |  |
IC50 | = | 7.0 | nM | 494.4 | O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 | Homo sapiens | CHEMBL698477 | single protein format |
| CHEMBL1098760 |  |
IC50 | = | 8.0 | nM | 537.36 | CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ncn1)C[C@H]2c1ccc(C#N)cc1 | Homo sapiens | CHEMBL1120946 | cell-based format |
| CHEMBL423725 |  |
IC50 | = | 8.0 | nM | 457.9 | COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL698473 | single protein format |