P20292 | AL5AP_HUMAN | Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01124 | MAPEG - MAPEG family | 11~127 |
3D structures mapped by conservation among orthologs
[ Domain: "MAPEG domain-like" // MAPEG ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5283430 |  |
IC50 | = | 0.5 | nM | 454.58 | CC(C)C(C)(c1ccc(-c2cnc(N)nc2)cc1)c1ccc(-c2ccc(C(C)(C)O)nn2)cn1 | Homo sapiens | CHEMBL5244383 | cell membrane format |
| CHEMBL5274418 |  |
IC50 | = | 0.7 | nM | 457.97 | Cc1ccn(-c2ccc(Cl)cc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)n1 | Homo sapiens | CHEMBL5244389 | cell-based format |
| CHEMBL5269712 |  |
IC50 | = | 0.7 | nM | 468.6 | CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2ccc(C(C)(C)O)nn2)cn1 | Homo sapiens | CHEMBL5244383 | cell membrane format |
| CHEMBL2031657 |  |
IC50 | = | 0.8 | nM | 489.58 | O=c1[nH]nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 | Homo sapiens | CHEMBL2033320 | assay format |
| CHEMBL3681322 |  |
IC50 | = | 0.91 | nM | 463.55 | CC(C)(C)n1c(-c2ccccc2C(=O)Nc2ccncc2)nc2cc(-c3cnc(N)nc3)ccc21 | Homo sapiens | CHEMBL3705412 | cell-based format |
| CHEMBL4080876 |  |
IC50 | = | 1.0 | nM | 412.46 | N#CCCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 | Homo sapiens | CHEMBL4047400 | cell-based format |
| CHEMBL4088763 |  |
IC50 | = | 1.0 | nM | 486.58 | CN(C(=O)Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1)C(C)(C)C | Homo sapiens | CHEMBL4047400 | cell-based format |
| CHEMBL2031658 |  |
IC50 | = | 1.1 | nM | 519.6 | COc1cccc([C@]2(c3cc(OCc4ccc5ccccc5n4)ccc3-c3n[nH]c(=O)o3)C[C@H]3CC[C@H]2C3)c1 | Homo sapiens | CHEMBL2033320 | assay format |
| CHEMBL3417524 |  |
IC50 | = | 1.1 | nM | 457.54 | CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4ccc(N)nc4)cc3)C3CC3)no2)cn1 | Homo sapiens | CHEMBL3420840 | cell-based format |
| CHEMBL5278870 |  |
IC50 | = | 1.1 | nM | 468.6 | COc1cncc(-c2ccc(C(C)(c3ccc(-c4ccc(C(C)(C)O)nn4)cn3)C(C)C)cc2)c1 | Homo sapiens | CHEMBL5244383 | cell membrane format |
| CHEMBL2031647 |  |
IC50 | = | 1.1 | nM | 505.64 | S=c1[nH]nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 | Homo sapiens | CHEMBL2033320 | assay format |
| CHEMBL3684717 |  |
IC50 | = | 1.2 | nM | 456.51 | Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CC[C@@H](O)C6)nc5)n4)CCC3)cn2)cn1 | Homo sapiens | CHEMBL3705124 | single protein format |
| CHEMBL3417526 |  |
IC50 | = | 1.2 | nM | 458.53 | CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)cn4)cc3)C3CC3)no2)cn1 | Homo sapiens | CHEMBL3420840 | cell-based format |
| CHEMBL3417520 |  |
IC50 | = | 1.3 | nM | 387.45 | Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)cn1 | Homo sapiens | CHEMBL3420840 | cell-based format |
| CHEMBL1922666 |  |
IC50 | = | 1.3 | nM | 593.79 | Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccccn3)cc2)nc1 | Homo sapiens | CHEMBL1924518 | assay format |
| CHEMBL4088331 |  |
IC50 | = | 1.5 | nM | 430.47 | C[C@@](c1ccc(-c2cnc(N)nc2)nc1)(c1noc(-c2cnn(C3COC3)c2)n1)C1CC1 | Homo sapiens | CHEMBL4047400 | cell-based format |
| CHEMBL3689122 |  |
IC50 | = | 1.5 | nM | 428.5 | CC(C)Nc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 | Homo sapiens | CHEMBL3705124 | single protein format |
| CHEMBL3681336 |  |
IC50 | = | 1.5 | nM | 463.55 | CC(C)(C)n1c(-c2ccccc2C(=O)Nc2cccnc2)nc2cc(-c3cnc(N)nc3)ccc21 | Homo sapiens | CHEMBL3705412 | cell-based format |
| CHEMBL3417518 |  |
IC50 | = | 1.6 | nM | 389.46 | CC(C)[C@](C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(-c2cnn(C)c2)n1 | Homo sapiens | CHEMBL3420840 | cell-based format |
| CHEMBL2031651 |  |
IC50 | = | 1.6 | nM | 487.6 | Cc1nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)no1 | Homo sapiens | CHEMBL2033320 | assay format |