P19801 | AOC1_HUMAN | Amiloride-sensitive amine oxidase [copper-containing] (AOC1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01179 | Cu_amine_oxid - Copper amine oxidase, enzyme domain | 301~708 | |
| PF02727 | Cu_amine_oxidN2 - Copper amine oxidase, N2 domain | 39~125 | |
| PF02728 | Cu_amine_oxidN3 - Copper amine oxidase, N3 domain | 141~241 |
3D structures mapped by conservation among orthologs
[ Domain: "supersandwich" // Cu_amine_oxid ]
[ Domain: "Amine oxidase N-terminal region" // Cu_amine_oxidN2 ]
[ Domain: "Amine oxidase N-terminal region" // Cu_amine_oxidN3 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL534467 |  |
IC50 | = | 61.0 | nM | 253.18 | CNc1cncc(N(C)C)c1CN.Cl.Cl | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL3921332 |  |
IC50 | < | 100.0 | nM | 224.24 | NC/C(=C/F)COc1ccc(C(N)=O)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3893265 |  |
IC50 | < | 100.0 | nM | 252.29 | CN(C)C(=O)c1ccc(OC/C(=C\F)CN)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL537845 |  |
IC50 | = | 120.0 | nM | 239.15 | CNc1cncc(NC)c1CN.Cl.Cl | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL534914 |  |
IC50 | = | 160.0 | nM | 210.11 | CNc1cnccc1CN.Cl.Cl | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL536953 |  |
IC50 | = | 300.0 | nM | 196.08 | Cl.Cl.NCc1ccncc1N | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL537624 |  |
IC50 | = | 500.0 | nM | 224.13 | CCNc1cnccc1CN.Cl.Cl | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL3953373 |  |
IC50 | < | 1000.0 | nM | 266.32 | Cc1cc(OC/C(=C\F)CN)ccc1C(=O)N(C)C | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3949163 |  |
IC50 | < | 1000.0 | nM | 238.26 | CNC(=O)c1ccc(OC/C(=C/F)CN)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3900277 |  |
IC50 | < | 1000.0 | nM | 331.18 | CN(C)C(=O)c1ccc(OC/C(=C\F)CN)c(Br)c1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3967909 |  |
IC50 | < | 1000.0 | nM | 260.29 | NC/C(=C/F)COc1ccc(S(N)(=O)=O)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3985531 |  |
IC50 | < | 1000.0 | nM | 270.28 | CN(C)C(=O)c1ccc(OC/C(=C\F)CN)c(F)c1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3924778 |  |
IC50 | < | 1000.0 | nM | 286.73 | CN(C)C(=O)c1ccc(OC/C(=C\F)CN)c(Cl)c1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3906960 |  |
IC50 | < | 1000.0 | nM | 288.34 | CCNS(=O)(=O)c1ccc(OC/C(=C\F)CN)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3915780 |  |
IC50 | < | 1000.0 | nM | 280.34 | CC(C)(C)NC(=O)c1ccc(OC/C(=C\F)CN)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL537405 |  |
IC50 | = | 1000.0 | nM | 309.29 | CC(C)Nc1cncc(N(C)C(C)C)c1CN.Cl.Cl | Homo sapiens | CHEMBL828122 | single protein format |
| CHEMBL3982106 |  |
IC50 | < | 1000.0 | nM | 282.31 | COc1cc(C(=O)N(C)C)ccc1OC/C(=C/F)CN | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL3897942 |  |
IC50 | < | 1000.0 | nM | 302.37 | CC(C)NS(=O)(=O)c1ccc(OC/C(=C\F)CN)cc1 | Homo sapiens | CHEMBL3888274 | single protein format |
| CHEMBL35241 |  |
Ki | = | 13.0 | nM | 281.32 | N=C(N)c1ccc(/N=N/Nc2ccc(C(=N)N)cc2)cc1 | Homo sapiens | CHEMBL3242684 | cell-based format |
| CHEMBL225304 |  |
Ki | = | 140.0 | nM | 74.09 | N=C(N)NN | Homo sapiens | CHEMBL668917 | single protein format |