P19793 | RXRA_HUMAN | Retinoic acid receptor RXR-alpha (RXRA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 265~441 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 134~202 | |
| PF11825 | Nuc_recep-AF1 - Nuclear/hormone receptor activator site AF-1 | 18~127 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
- 1FBY
- 1FM6
- 1FM9
- 1G1U
- 1G5Y
- 1K74
- 1MV9
- 1MVC
- 1MZN
- 1RDT
- 1XLS
- 1XV9
- 1XVP
- 2ACL
- 2P1T
- 2P1U
- 2P1V
- 2ZXZ
- 2ZY0
- 3DZU
- 3DZY
- 3E00
- 3E94
- 3FAL
- 3FC6
- 3FUG
- 3H0A
- 3KWY
- 3NSP
- 3NSQ
- 3OAP
- 3OZJ
- 3PCU
- 3R29
- 3R2A
- 3R5M
- 3UVV
- 4J5W
- 4J5X
- 4K4J
- 4K6I
- 4M8E
- 4M8H
- 4N5G
- 4N8R
- 4NQA
- 4OC7
- 4POH
- 4POJ
- 4PP3
- 4PP5
- 4RFW
- 4RMC
- 4RMD
- 4RME
- 4ZO1
- 4ZSH
- 5EC9
- 5JI0
- 5LYQ
- 5MJ5
- 5MK4
- 5MKJ
- 5MKU
- 5MMW
- 5TBP
- 5UAN
- 5Z12
- 5ZQU
- 6A5Y
- 6A5Z
- 6A60
- 6HN6
- 6JNO
- 6SJM
- 6STI
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL366112 |  |
IC50 | = | 6.0 | nM | 419.57 | CCCOc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cn1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL184497 |  |
IC50 | = | 10.0 | nM | 433.59 | CCCCOc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cn1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL277626 |  |
IC50 | = | 21.0 | nM | 374.52 | Cc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL32505 |  |
IC50 | = | 32.0 | nM | 362.51 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798314 | single protein format |
| CHEMBL705 |  |
IC50 | = | 32.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL798314 | single protein format |
| CHEMBL187021 |  |
IC50 | = | 120.0 | nM | 418.58 | CCCOc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL188581 |  |
IC50 | = | 270.0 | nM | 432.6 | CCCCOc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL3098771 |  |
IC50 | = | 284.0 | nM | 294.39 | CC(=C/C=C/C(C)=C/C(=O)O)/C=C1\CCCc2ccccc21 | Homo sapiens | CHEMBL5241646 | single protein format |
| CHEMBL284937 |  |
IC50 | = | 320.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798314 | single protein format |
| CHEMBL424636 |  |
IC50 | = | 320.0 | nM | 390.57 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C(C)C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798314 | single protein format |
| CHEMBL427694 |  |
IC50 | = | 410.0 | nM | 573.76 | CCCCNS(=O)(=O)c1ccc2c(c1)N=C(c1ccc(C(=O)O)cc1)c1cc3c(cc1N2C)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889747 | single protein format |
| CHEMBL244832 |  |
IC50 | = | 480.0 | nM | 477.61 | CCN1c2ccc(C#N)cc2N=C(c2ccc(C(=O)O)cc2)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889747 | single protein format |
| CHEMBL188638 |  |
IC50 | = | 500.0 | nM | 416.61 | CCCCc1cc2c(cc1C(=C1CC1)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL832609 | assay format |
| CHEMBL396200 |  |
IC50 | = | 520.0 | nM | 481.57 | CN1c2ccc(C#N)cc2N=C(c2ccc(C(=O)O)c(F)c2)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889748 | single protein format |
| CHEMBL242274 |  |
IC50 | = | 530.0 | nM | 495.6 | CCN1c2ccc(C#N)cc2N=C(c2ccc(C(=O)O)cc2F)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889748 | single protein format |
| CHEMBL1023 |  |
IC50 | = | 632.0 | nM | 348.49 | C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL4715623 | assay format |
| CHEMBL438857 |  |
IC50 | = | 670.0 | nM | 595.21 | CN1c2ccc(SCc3ccc(Cl)cc3)cc2N=C(c2ccc(C(=O)O)cc2)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889748 | single protein format |
| CHEMBL395563 |  |
IC50 | = | 720.0 | nM | 576.76 | COc1ccc(Sc2ccc3c(c2)N=C(c2ccc(C(=O)O)cc2)c2cc4c(cc2N3C)C(C)(C)CCC4(C)C)cc1 | Homo sapiens | CHEMBL889748 | single protein format |
| CHEMBL398163 |  |
IC50 | = | 770.0 | nM | 495.6 | CCN1c2ccc(C#N)cc2N=C(c2ccc(C(=O)O)c(F)c2)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889747 | single protein format |
| CHEMBL244621 |  |
IC50 | = | 820.0 | nM | 463.58 | CN1c2ccc(C#N)cc2N=C(c2ccc(C(=O)O)cc2)c2cc3c(cc21)C(C)(C)CCC3(C)C | Homo sapiens | CHEMBL889747 | single protein format |