P19634 | SL9A1_HUMAN | Sodium/hydrogen exchanger 1 (SLC9A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00999 | Na_H_Exchanger - Sodium/hydrogen exchanger, transmembrane | 110~503 | |
| PF16644 | NEXCaM_BD - Regulatory region of Na+/H+ exchanger NHE binds to calmodulin | 600~685 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL392093 |  |
IC50 | = | 0.48 | nM | 367.24 | NC(N)=NC(=O)c1oc(-c2cc(Cl)ccc2Cl)cc1N1CCCC1 | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL3980085 |  |
IC50 | = | 1.0 | nM | 310.38 | Cc1ccc(F)cc1[C@@H]1C/C(=N\N=C(N)N)c2ccccc2C1 | Homo sapiens | CHEMBL3881459 | cell-based format |
| CHEMBL3900790 |  |
IC50 | = | 1.0 | nM | 324.4 | Cc1ccc(F)cc1[C@@H]1C/C(=N\N=C(N)N)c2c(C)cccc2C1 | Homo sapiens | CHEMBL3882215 | single protein format |
| CHEMBL3900457 |  |
IC50 | = | 2.0 | nM | 328.38 | C/C(=C\c1cccc(/C=C(\C)C(=O)NC(=N)N)c1)C(=O)N=C(N)N | Homo sapiens | CHEMBL3881459 | cell-based format |
| CHEMBL384143 |  |
IC50 | = | 4.6 | nM | 390.47 | Cc1cc(-c2cnc(CC#N)nc2N2CCC(c3[nH]cnc3C)CC2)ccc1F | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL211924 |  |
IC50 | = | 5.4 | nM | 386.86 | Cc1[nH]c(N)nc1C1CCN(c2ncncc2-c2ccc(F)c(Cl)c2)CC1 | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL217698 |  |
IC50 | = | 6.5 | nM | 381.45 | COc1ncc(-c2ccc(F)c(C)c2)c(N2CCC(c3[nH]cnc3C)CC2)n1 | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL213568 |  |
IC50 | = | 7.4 | nM | 409.51 | Cc1cc(-c2cnc(OC(C)C)nc2N2CCC(c3[nH]cnc3C)CC2)ccc1F | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL394633 |  |
IC50 | = | 8.0 | nM | 313.14 | NC(N)=NC(=O)c1oc(-c2cc(Cl)ccc2Cl)cc1N | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL51879 |  |
IC50 | = | 9.0 | nM | 273.34 | CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1cccc2c1CCO2 | Homo sapiens | CHEMBL3881456 | cell-based format |
| CHEMBL395897 |  |
IC50 | = | 9.0 | nM | 341.2 | CN(C)c1cc(-c2cc(Cl)ccc2Cl)oc1C(=O)N=C(N)N | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL232748 |  |
IC50 | = | 10.0 | nM | 307.74 | COc1ccc(Cl)cc1-c1cc(C)c(C(=O)N=C(N)N)o1 | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL395898 |  |
IC50 | = | 12.0 | nM | 336.78 | COc1ccc(Cl)cc1-c1cc(N(C)C)c(C(=O)N=C(N)N)o1 | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL232940 |  |
IC50 | = | 15.0 | nM | 308.73 | COc1ccc(Cl)cc1-c1cc(N)c(C(=O)N=C(N)N)o1 | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL385944 |  |
IC50 | = | 15.0 | nM | 401.87 | COc1ncc(-c2ccc(F)c(Cl)c2)c(N2CCC(c3[nH]cnc3C)CC2)n1 | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL397141 |  |
IC50 | = | 16.0 | nM | 312.16 | Cc1cc(-c2cc(Cl)ccc2Cl)oc1C(=O)N=C(N)N | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL376979 |  |
IC50 | = | 21.0 | nM | 351.43 | Cc1cc(-c2cncnc2N2CCC(c3[nH]cnc3C)CC2)ccc1F | Homo sapiens | CHEMBL856311 | cell-based format |
| CHEMBL2170615 |  |
IC50 | = | 23.0 | nM | 497.5 | N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(S(N)(=O)=O)cc3)CC2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL2173434 | cell-free format |
| CHEMBL396615 |  |
IC50 | = | 24.0 | nM | 277.71 | Cc1cc(-c2cccc(Cl)c2)oc1C(=O)N=C(N)N | Homo sapiens | CHEMBL895927 | cell-based format |
| CHEMBL232974 |  |
IC50 | = | 24.0 | nM | 243.27 | Cc1cc(-c2ccccc2)oc1C(=O)N=C(N)N | Homo sapiens | CHEMBL895927 | cell-based format |