P19525 | E2AK2_HUMAN | Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00035 | dsrm - Double-stranded RNA binding motif | 13~75 | |
| PF00035 | dsrm - Double-stranded RNA binding motif | 101~164 | |
| PF00069 | Pkinase - Protein kinase domain | 268~534 |
3D structures mapped by conservation among orthologs
[ Domain: "dsRNA-binding domain-like" // dsrm ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2441346 |  |
IC50 | = | 99.0 | nM | 419.46 | Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 | Homo sapiens | CHEMBL2443946 | single protein format |
| CHEMBL1182777 |  |
IC50 | < | 100.0 | nM | 314.3 | O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL191384 |  |
IC50 | < | 100.0 | nM | 372.46 | N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL388978 |  |
IC50 | < | 100.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL416056 |  |
IC50 | < | 100.0 | nM | 467.48 | COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL413188 |  |
IC50 | < | 100.0 | nM | 276.26 | O=C1NC(=O)c2c1c1c3ccccc3[nH]c1n1cncc21 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL1802727 |  |
IC50 | < | 100.0 | nM | 365.39 | O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCCC(O)CO | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL1802782 |  |
IC50 | = | 100.0 | nM | 432.96 | Cc1[nH]c2ccc(Cl)cc2c1-c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL126077 |  |
IC50 | < | 100.0 | nM | 277.28 | O=Nc1c(-c2c(O)[nH]c3ccccc23)[nH]c2ccccc12 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL1802629 |  |
IC50 | = | 100.0 | nM | 301.35 | Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccnc2)n1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL1802778 |  |
IC50 | = | 150.0 | nM | 318.36 | Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL4281823 |  |
IC50 | = | 210.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261425 | single protein format |
| CHEMBL200381 |  |
IC50 | = | 250.0 | nM | 404.84 | N#Cc1cnc2cnc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL257167 |  |
IC50 | = | 250.0 | nM | 279.3 | NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL2171122 |  |
IC50 | = | 291.0 | nM | 417.9 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172951 | single protein format |
| CHEMBL1802769 |  |
IC50 | = | 300.0 | nM | 334.81 | Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccc(Cl)c2)n1 | Homo sapiens | CHEMBL1805140 | single protein format |
| CHEMBL5271785 |  |
IC50 | = | 306.0 | nM | 496.6 | CC(=O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(C)c5)cc4)csc23)cn1 | Homo sapiens | CHEMBL5225231 | single protein format |
| CHEMBL2441342 |  |
IC50 | = | 359.0 | nM | 470.43 | Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2443946 | single protein format |
| CHEMBL5266620 |  |
IC50 | = | 364.0 | nM | 552.01 | COCCO[C@H]1CC[C@H](n2nc(-c3ccc(Nc4nc5cc(Cl)cc(F)c5o4)cc3)c3c(N)ncnc32)CC1 | Homo sapiens | CHEMBL5225231 | single protein format |
| CHEMBL5267979 |  |
IC50 | = | 475.0 | nM | 572.94 | Nc1ncc(-c2nnn(CCCO)n2)cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)ccc2o1 | Homo sapiens | CHEMBL5225232 | single protein format |