P19438 | TNR1A_HUMAN | Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00020 | TNFR_c6 - TNFR/NGFR cysteine-rich region | 84~125 | |
| PF00020 | TNFR_c6 - TNFR/NGFR cysteine-rich region | 127~166 | |
| PF00531 | Death - Death domain | 358~440 |
3D structures mapped by conservation among orthologs
[ Domain: "DEATH domain" // Death ]
[ Domain: "TNF receptor-like" // TNFR_c6_2 ]
[ Domain: "TNF receptor-like" // TNFR_c6_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL359346 |  |
IC50 | = | 130.0 | nM | 341.44 | CCN1C(=O)C(=Cc2cn(C)c3ccccc23)C(=O)N(CC)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL357092 |  |
IC50 | = | 140.0 | nM | 403.48 | CCN1C(=O)/C(=C/c2ccc(-c3cc(C(F)(F)F)nn3C)s2)SC1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL150292 |  |
IC50 | = | 210.0 | nM | 316.38 | C=CCN1C(=O)n2c(c(C)c3c(OC)cc(OC)cc32)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL356012 |  |
IC50 | = | 210.0 | nM | 332.45 | C=CCN1C(=S)c2c(C)c3c(OC)cc(OC)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL356830 |  |
IC50 | = | 280.0 | nM | 302.36 | C=CCN1C(=O)c2cc3c(OC)cc(OC)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL151203 |  |
IC50 | = | 280.0 | nM | 320.37 | CCN1C(=O)c2cc3c(OC)cc(OCOC)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL150886 |  |
IC50 | = | 300.0 | nM | 379.48 | CCN1C(=O)/C(=C/c2ccc(-c3ccsc3C(=O)OC)o2)SC1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL423208 |  |
IC50 | = | 310.0 | nM | 367.43 | CCN1C(=O)c2cc3c(OC)cc(OCc4ccccn4)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL146955 |  |
IC50 | = | 320.0 | nM | 383.42 | CCN1C(=O)/C(=C/c2ccc(-c3ccccc3C(F)(F)F)o2)SC1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL151686 |  |
IC50 | = | 390.0 | nM | 390.46 | CCN1C(=O)c2cc3c(OC)cc(OCC(=O)OC(C)(C)C)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL150992 |  |
IC50 | = | 400.0 | nM | 433.53 | CCN1C(=O)C(=Cc2c[nH]c3ccc(OCc4ccccc4)cc23)C(=O)N(CC)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL359348 |  |
IC50 | = | 600.0 | nM | 341.44 | CCN1C(=O)C(=Cc2c[nH]c3c(C)cccc23)C(=O)N(CC)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL345772 |  |
IC50 | = | 610.0 | nM | 302.36 | C=CCN1C(=O)n2c(cc3c(OC)cc(OC)cc32)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL355913 |  |
IC50 | = | 670.0 | nM | 389.48 | COc1cc(OC)c2cc3n(c2c1)C(=S)N(CCCN1CCOCC1)C3=O | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL4213787 |  |
IC50 | = | 770.0 | nM | 393.25 | O=C(NNC(=O)c1csc(-c2ccc(Cl)cc2Cl)n1)c1ccccn1 | Homo sapiens | CHEMBL4195488 | cell-based format |
| CHEMBL151752 |  |
IC50 | = | 780.0 | nM | 332.38 | C=CCN1C(=O)c2cc3c(OC)c(OC)c(OC)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL347715 |  |
IC50 | = | 790.0 | nM | 451.55 | Cc1ccccc1N1C(=O)C(=Cc2c[nH]c3ccccc23)C(=O)N(c2ccccc2C)C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL151578 |  |
IC50 | = | 1000.0 | nM | 290.34 | CCN1C(=O)c2cc3c(OC)cc(OC)cc3n2C1=S | Homo sapiens | CHEMBL817776 | single protein format |
| CHEMBL345500 |  |
IC50 | = | 1000.0 | nM | 327.41 | CCN1C(=O)C(=Cc2c[nH]c3ccccc23)C(=O)N(CC)C1=S | Homo sapiens | CHEMBL817776 | single protein format |