P19174 | PLCG1_HUMAN | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 | 550–639 | |
| PF00017 | SH2 | 668–741 | |
| PF00018 | SH3_1 | 797–843 | |
| PF00168 | C2 | 1090–1186 | |
| PF00169 | PH | 57–140 | |
| PF00387 | PI-PLC-Y | 953–1067 | |
| PF00388 | PI-PLC-X | 322–465 | |
| PF23329 | EF_HAND_1_PLCG | 146–220 | |
| PF23583 | EF_HAND_2_PLCG | 243–313 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "SH2" // SH2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3355737 |  |
IC50 | = | 180.0 | nM | 481.62 | O=S(=O)(c1ccccc1)c1cc(Nc2cc(C3CCCC3)[nH]n2)nc(N[C@H]2CC[C@H](O)CC2)c1 | Homo sapiens | CHEMBL3390067 | cell-based format |
| CHEMBL3355726 |  |
IC50 | = | 540.0 | nM | 427.53 | Cc1cc(Nc2cc(S(=O)(=O)c3ccccc3)cc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1 | Homo sapiens | CHEMBL3390067 | cell-based format |