P18825 | ADA2C_HUMAN | Alpha-2C adrenergic receptor (ADRA2C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 68~437 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL157138 |  |
IC50 | = | 4.308 | nM | 338.46 | CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL42 |  |
IC50 | = | 7.875 | nM | 326.83 | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL85 |  |
IC50 | = | 9.557 | nM | 410.49 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL1732 |  |
IC50 | = | 10.0 | nM | 583.69 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL442 |  |
IC50 | = | 12.0 | nM | 581.67 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL1385840 |  |
IC50 | = | 17.0 | nM | 561.68 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL537669 |  |
IC50 | = | 27.1 | nM | 390.91 | COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O.Cl | Homo sapiens | CHEMBL1046750 | single protein format |
| CHEMBL15245 |  |
IC50 | = | 36.0 | nM | 354.45 | COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL1403281 |  |
IC50 | = | 38.0 | nM | 575.71 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL1909072 |  |
IC50 | = | 45.0 | nM | 401.96 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL629 |  |
IC50 | = | 59.0 | nM | 277.41 | CN(C)CCC=C1c2ccccc2CCc2ccccc21 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL728 |  |
IC50 | = | 82.0 | nM | 373.95 | CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL723 |  |
IC50 | = | 90.0 | nM | 406.48 | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL1626 |  |
IC50 | = | 95.0 | nM | 343.9 | CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL597 |  |
IC50 | = | 110.0 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL726 |  |
IC50 | = | 154.0 | nM | 437.53 | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL479 |  |
IC50 | = | 171.0 | nM | 370.59 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL6437 |  |
IC50 | = | 179.0 | nM | 264.37 | CN1CCN2c3ccccc3Cc3ccccc3C2C1 | Homo sapiens | CHEMBL1909090 | cell membrane format |
| CHEMBL4636550 |  |
IC50 | = | 180.0 | nM | 304.19 | Cc1cc(Br)c(NC2=NCCN2)c2ccccc12 | Homo sapiens | CHEMBL4614750 | single protein format |
| CHEMBL50588 |  |
IC50 | = | 182.0 | nM | 480.65 | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | Homo sapiens | CHEMBL1909090 | cell membrane format |