P18405 | S5A1_HUMAN | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02544 | Steroid_dh - 3-oxo-5-alpha-steroid 4-dehydrogenase | 111~259 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL421627 |  |
IC50 | = | 0.6 | nM | 413.69 | CC(C)CCCC(C)C1CCC2C3C(CC[C@]12C)[C@@]1(C)CCC(=O)N(C)C1=C[C@@H]3C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL420415 |  |
IC50 | = | 0.9 | nM | 495.11 | C[C@]12C=CC(=O)NC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)NC1(c2ccc(Cl)cc2)CCCC1 | Homo sapiens | CHEMBL804516 | single protein format |
| CHEMBL25448 |  |
IC50 | = | 0.9 | nM | 415.71 | CC(C)CCCC(C)[C@H]1CCC2C3C(CC[C@@]21C)[C@@]1(C)CCC(=O)N(C)C1C[C@@H]3C | Homo sapiens | CHEMBL816491 | single protein format |
| CHEMBL275153 |  |
IC50 | = | 0.91 | nM | 402.62 | CCCCCN(C=O)[C@H]1CCC2C3CC[C@H]4N(C)C(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL126686 |  |
IC50 | = | 1.6 | nM | 399.66 | CC(C)CCCC(C)C1CCC2C3C(CC[C@]12C)[C@@]1(C)C=CC(=O)NC1C[C@@H]3C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL340027 |  |
IC50 | = | 1.7 | nM | 401.68 | CC(C)CCCC(C)C1CCC2C3CCC4N(C)C(=O)CC[C@]4(C)C3CC[C@]12C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL24193 |  |
IC50 | = | 1.7 | nM | 401.68 | CC(C)CCCC(C)[C@H]1CCC2C3CCC4N(C)C(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL816491 | single protein format |
| CHEMBL2298601 |  |
IC50 | = | 1.7 | nM | 388.6 | CCN(CC)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C | Homo sapiens | CHEMBL816491 | single protein format |
| CHEMBL280015 |  |
IC50 | = | 1.77 | nM | 458.73 | CCCCCN(C(=O)CCCC)[C@H]1CCC2C3CC[C@H]4N(C)C(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL128023 |  |
IC50 | = | 2.0 | nM | 413.69 | CC(C)CCCC(C)C1CCC2C3C(CC[C@]12C)[C@@]1(C)C=CC(=O)N(C)C1C[C@@H]3C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL17245 |  |
IC50 | = | 2.11 | nM | 514.71 | COc1ccc(N(C(=O)c2ccccc2)[C@H]2CCC3C4CC[C@H]5N(C)C(=O)CC[C@]5(C)C4CC[C@@]32C)cc1 | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL17222 |  |
IC50 | = | 2.19 | nM | 402.62 | CC(C)CCN(C=O)[C@H]1CCC2C3CC[C@H]4N(C)C(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL16863 |  |
IC50 | = | 2.35 | nM | 416.65 | CN1C(=O)CC[C@]2(C)C3CC[C@@]4(C)C(CC[C@@H]4N(C=O)CCC(C)(C)C)C3CC[C@@H]12 | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL283245 |  |
IC50 | = | 2.4 | nM | 528.54 | C[C@]12C=CC(=O)NC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)Nc1cc(C(F)(F)F)ccc1C(F)(F)F | Homo sapiens | CHEMBL816491 | single protein format |
| CHEMBL274269 |  |
IC50 | = | 2.42 | nM | 537.63 | CCCCCN(C(=O)CCCCBr)[C@H]1CCC2C3CC[C@H]4N(C)C(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL805444 | cell-based format |
| CHEMBL338376 |  |
IC50 | = | 2.5 | nM | 399.66 | CC(C)CCCC(C)C1CCC2C3C(CC[C@]12C)[C@@]1(C)CCC(=O)NC1=C[C@@H]3C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL340181 |  |
IC50 | = | 2.6 | nM | 387.65 | CC(C)CCCC(C)C1CCC2C3CCC4NC(=O)CC[C@]4(C)C3CC[C@]12C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL340715 |  |
IC50 | = | 2.6 | nM | 401.68 | CC(C)CCCC(C)C1CCC2C3C(CC[C@]12C)[C@@]1(C)CCC(=O)NC1C[C@@H]3C | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL340684 |  |
IC50 | = | 2.7 | nM | 415.71 | CC[C@H]1CC2NC(=O)CC[C@]2(C)C2CC[C@]3(C)C(C(C)CCCC(C)C)CCC3C21 | Homo sapiens | CHEMBL816487 | single protein format |
| CHEMBL276320 |  |
IC50 | = | 2.93 | nM | 484.68 | CN1C(=O)CC[C@]2(C)C3CC[C@@]4(C)C(CC[C@@H]4N(C(=O)c4ccccc4)c4ccccc4)C3CC[C@@H]12 | Homo sapiens | CHEMBL805444 | cell-based format |