P18089 | ADA2B_HUMAN | Alpha-2B adrenergic receptor (ADRA2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 29~426 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL157138 |  |
IC50 | = | 0.518 | nM | 338.46 | CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL1909072 |  |
IC50 | = | 1.722 | nM | 401.96 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL1385840 |  |
IC50 | = | 3.058 | nM | 561.68 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL442 |  |
IC50 | = | 3.844 | nM | 581.67 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL1732 |  |
IC50 | = | 3.867 | nM | 583.69 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL629 |  |
IC50 | = | 8.076 | nM | 277.41 | CN(C)CCC=C1c2ccccc2CCc2ccccc21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL728 |  |
IC50 | = | 10.0 | nM | 373.95 | CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL19215 |  |
IC50 | = | 16.0 | nM | 403.53 | CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL15245 |  |
IC50 | = | 17.0 | nM | 354.45 | COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL564 |  |
IC50 | = | 18.0 | nM | 284.43 | CN(C)CCCN1c2ccccc2Sc2ccccc21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL597 |  |
IC50 | = | 18.0 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL42 |  |
IC50 | = | 23.0 | nM | 326.83 | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL71 |  |
IC50 | = | 26.0 | nM | 318.87 | CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL85 |  |
IC50 | = | 26.0 | nM | 410.49 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL1403281 |  |
IC50 | = | 26.0 | nM | 575.71 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL726 |  |
IC50 | = | 29.0 | nM | 437.53 | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL516 |  |
IC50 | = | 38.0 | nM | 287.41 | CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL6437 |  |
IC50 | = | 52.0 | nM | 264.37 | CN1CCN2c3ccccc3Cc3ccccc3C2C1 | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL643 |  |
IC50 | = | 53.0 | nM | 284.43 | CC(CN1c2ccccc2Sc2ccccc21)N(C)C | Homo sapiens | CHEMBL1909089 | cell membrane format |
| CHEMBL531 |  |
IC50 | = | 64.0 | nM | 314.5 | CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909089 | cell membrane format |