P17948 | VGFR1_HUMAN | Vascular endothelial growth factor receptor 1 (FLT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00047 | ig - Immunoglobulin domain | 239~321 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 350~407 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 662~748 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 827~1154 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 568~640 | |
| PF17988 | VEGFR-2_TMD - VEGFR-2 Transmembrane domain | 753~787 | |
| PF21339 | VEGFR-1-like_Ig-like - Vascular endothelial growth factor receptor 1-like, Ig-like domain | 143~224 | |
| PF22854 | VEGFR1-3_N_Ig-like - VEGFR1-3, N-terminal Ig-like domain | 26~137 | |
| PF22971 | Ig_VEGFR-1-like_5th - VEGFR-1-like, immunoglobulin-like domain | 426~556 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // C1-set_3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_9 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_9,I-set_13 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3939307 |  |
IC50 | = | 0.1 | nM | 388.5 | CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 | Homo sapiens | CHEMBL3871601 | single protein format |
| CHEMBL1289926 |  |
IC50 | = | 0.1 | nM | 386.48 | CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 | Homo sapiens | CHEMBL4271313 | single protein format |
| CHEMBL1289494 |  |
IC50 | = | 0.21 | nM | 454.87 | COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC | Homo sapiens | CHEMBL2186469 | single protein format |
| CHEMBL429743 |  |
IC50 | = | 0.5 | nM | 484.94 | COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1OC | Homo sapiens | CHEMBL933144 | single protein format |
| CHEMBL5412144 |  |
IC50 | = | 0.86 | nM | 580.09 | COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328004 | single protein format |
| CHEMBL5403470 |  |
IC50 | = | 0.88 | nM | 580.06 | COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)c(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328004 | single protein format |
| CHEMBL535 |  |
IC50 | = | 1.0 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL2090041 | single protein format |
| CHEMBL4062877 |  |
IC50 | = | 1.0 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 | Homo sapiens | CHEMBL4018637 | single protein format |
| CHEMBL378024 |  |
IC50 | = | 1.0 | nM | 514.68 | CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)c2c1 | Homo sapiens | CHEMBL862849 | single protein format |
| CHEMBL5393865 |  |
IC50 | = | 1.03 | nM | 580.06 | COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328004 | single protein format |
| CHEMBL5438830 |  |
IC50 | = | 1.07 | nM | 553.02 | COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328004 | single protein format |
| CHEMBL2180602 |  |
IC50 | = | 1.3 | nM | 424.52 | CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 | Homo sapiens | CHEMBL2434170 | single protein format |
| CHEMBL3646211 |  |
IC50 | = | 1.45 | nM | 530.61 | COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](O)CO)c5)cnc(N)c34)cc2)cc1 | Homo sapiens | CHEMBL3707719 | single protein format |
| CHEMBL1969102 |  |
IC50 | = | 1.9 | nM | 440.53 | Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 | Homo sapiens | CHEMBL3707719 | single protein format |
| CHEMBL311109 |  |
IC50 | = | 2.0 | nM | 482.61 | NC(=O)C1CCN(Cc2ccc(-c3cc4ncnc(Nc5ccc6[nH]ccc6c5)c4s3)cc2)CC1 | Homo sapiens | CHEMBL811929 | single protein format |
| CHEMBL390156 |  |
IC50 | = | 2.0 | nM | 480.64 | CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 | Homo sapiens | CHEMBL914193 | single protein format |
| CHEMBL1271641 |  |
IC50 | = | 2.0 | nM | 432.48 | Oc1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1O | Homo sapiens | CHEMBL1272381 | single protein format |
| CHEMBL572881 |  |
IC50 | = | 2.0 | nM | 373.46 | CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 | Homo sapiens | CHEMBL2186469 | single protein format |
| CHEMBL3660275 |  |
IC50 | = | 2.0 | nM | 428.45 | Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)O)c[nH]4)c3)cc2)c1 | Homo sapiens | CHEMBL3707664 | single protein format |
| CHEMBL377230 |  |
IC50 | = | 2.0 | nM | 468.53 | FC(F)(F)c1ccc2c(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)[nH]nc2c1 | Homo sapiens | CHEMBL862849 | single protein format |