P17752 | TPH1_HUMAN | Tryptophan 5-hydroxylase 1 (TPH1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00351 | Biopterin_H - Biopterin-dependent aromatic amino acid hydroxylase | 106~435 |
3D structures mapped by conservation among orthologs
[ Domain: "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains" // Biopterin_H ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL3799301 | IC50 | = | 6.0 | nM | 583.61 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccc(C(F)(F)F)cc2)cccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3800397 | IC50 | = | 6.0 | nM | 550.06 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2cccc(Cl)c2)cccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3797264 | IC50 | = | 6.0 | nM | 545.64 | COc1cccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)c1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799331 | IC50 | = | 7.0 | nM | 506.63 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1cc(-c2nccs2)ccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL567046 | IC50 | = | 7.0 | nM | 440.51 | Nc1nc(NCc2ccccc2-c2ccccc2)nc(-c2ccc(C[C@H](N)C(=O)O)cc2)n1 | Homo sapiens | CHEMBL1042730 | single protein format | |
CHEMBL3798045 | IC50 | = | 8.0 | nM | 529.64 | Cc1cccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)c1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799810 | IC50 | = | 10.0 | nM | 545.64 | COc1ccccc1Oc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799287 | IC50 | = | 10.0 | nM | 583.61 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccccc2C(F)(F)F)cccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3800151 | IC50 | = | 11.0 | nM | 529.64 | Cc1ccccc1Oc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3798880 | IC50 | = | 11.0 | nM | 550.06 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccc(Cl)cc2)cccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799498 | IC50 | = | 11.0 | nM | 491.51 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(N2CCCCC2)cccc1C(F)(F)F | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3797282 | IC50 | = | 11.0 | nM | 435.53 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1ccccc1N1CC2CCC1C2 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799767 | IC50 | = | 12.0 | nM | 437.54 | Cc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3797766 | IC50 | = | 13.0 | nM | 529.64 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccccc2)cccc1N1CCCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL518324 | IC50 | = | 13.0 | nM | 398.47 | N[C@@H](Cc1ccc(-c2cnc(NCc3ccc4ccccc4c3)cn2)cc1)C(=O)O | Homo sapiens | CHEMBL1016550 | single protein format | |
CHEMBL3797417 | IC50 | = | 14.0 | nM | 499.62 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1cc(-c2ccccc2)ccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799918 | IC50 | = | 14.0 | nM | 583.61 | N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2cccc(C(F)(F)F)c2)cccc1N1CCCCC1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL569291 | IC50 | = | 14.0 | nM | 454.53 | Cc1ccc(-c2ccc(CNc3nc(N)nc(-c4ccc(C[C@H](N)C(=O)O)cc4)n3)cc2)cc1 | Homo sapiens | CHEMBL1042730 | single protein format | |
CHEMBL3797220 | IC50 | = | 15.0 | nM | 437.54 | CC1CCCCN1c1ccccc1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 | Homo sapiens | CHEMBL3802442 | single protein format | |
CHEMBL3799711 | IC50 | = | 15.0 | nM | 529.64 | Cc1ccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3802442 | single protein format |