P17752 | TPH1_HUMAN | Tryptophan 5-hydroxylase 1 (TPH1)

Pfam Domain Table

AccessionDomainRangeColor
PF00351Biopterin_H - Biopterin-dependent aromatic amino acid hydroxylase106~435

3D structures mapped by conservation among orthologs

[ Domain: "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains" // Biopterin_H ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3799301 IC50 = 6.0 nM 583.61 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccc(C(F)(F)F)cc2)cccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3800397 IC50 = 6.0 nM 550.06 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2cccc(Cl)c2)cccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3797264 IC50 = 6.0 nM 545.64 COc1cccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)c1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799331 IC50 = 7.0 nM 506.63 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1cc(-c2nccs2)ccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL567046 IC50 = 7.0 nM 440.51 Nc1nc(NCc2ccccc2-c2ccccc2)nc(-c2ccc(C[C@H](N)C(=O)O)cc2)n1 Homo sapiens CHEMBL1042730 single protein format
CHEMBL3798045 IC50 = 8.0 nM 529.64 Cc1cccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)c1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799810 IC50 = 10.0 nM 545.64 COc1ccccc1Oc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799287 IC50 = 10.0 nM 583.61 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccccc2C(F)(F)F)cccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3800151 IC50 = 11.0 nM 529.64 Cc1ccccc1Oc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3798880 IC50 = 11.0 nM 550.06 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccc(Cl)cc2)cccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799498 IC50 = 11.0 nM 491.51 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(N2CCCCC2)cccc1C(F)(F)F Homo sapiens CHEMBL3802442 single protein format
CHEMBL3797282 IC50 = 11.0 nM 435.53 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1ccccc1N1CC2CCC1C2 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799767 IC50 = 12.0 nM 437.54 Cc1cccc(N2CCCCC2)c1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3797766 IC50 = 13.0 nM 529.64 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2ccccc2)cccc1N1CCCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL518324 IC50 = 13.0 nM 398.47 N[C@@H](Cc1ccc(-c2cnc(NCc3ccc4ccccc4c3)cn2)cc1)C(=O)O Homo sapiens CHEMBL1016550 single protein format
CHEMBL3797417 IC50 = 14.0 nM 499.62 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1cc(-c2ccccc2)ccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799918 IC50 = 14.0 nM 583.61 N/C(=N\C(=O)c1ccc(C[C@H](N)C(=O)O)cc1)NCc1c(Oc2cccc(C(F)(F)F)c2)cccc1N1CCCCC1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL569291 IC50 = 14.0 nM 454.53 Cc1ccc(-c2ccc(CNc3nc(N)nc(-c4ccc(C[C@H](N)C(=O)O)cc4)n3)cc2)cc1 Homo sapiens CHEMBL1042730 single protein format
CHEMBL3797220 IC50 = 15.0 nM 437.54 CC1CCCCN1c1ccccc1CN/C(N)=N/C(=O)c1ccc(C[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL3802442 single protein format
CHEMBL3799711 IC50 = 15.0 nM 529.64 Cc1ccc(Oc2cccc(N3CCCCC3)c2CN/C(N)=N/C(=O)c2ccc(C[C@H](N)C(=O)O)cc2)cc1 Homo sapiens CHEMBL3802442 single protein format