P17706 | PTN2_HUMAN | Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 42~274 |
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5093253 |  |
IC50 | < | 1.0 | nM | 423.42 | CC(C)(C#N)CCOc1cc2c(F)c(N3CC(=O)NS3(=O)=O)c(O)cc2cc1O | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5084112 |  |
IC50 | = | 1.0 | nM | 394.43 | O=C1CN(c2c(O)cc3ccc(NCCN4CCC4)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5076419 |  |
IC50 | = | 1.0 | nM | 379.41 | O=C1CN(c2c(O)cc3ccc(NCCC4CC4)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5070507 |  |
IC50 | < | 1.0 | nM | 469.52 | O=C1CN(c2c(O)cc3ccc(C4CCN(S(=O)(=O)C5CC5)C4)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5085502 |  |
IC50 | < | 1.0 | nM | 407.42 | CC(C)(C#N)CCOc1ccc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2c1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5092308 |  |
IC50 | < | 1.0 | nM | 416.43 | O=C1CN(c2c(O)cc3ccc(-c4cnn(CC5CC5)c4)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5085615 |  |
IC50 | < | 1.0 | nM | 384.39 | C[C@H](O)CCOc1ccc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2c1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5080612 |  |
IC50 | < | 1.0 | nM | 497.57 | CC(C)CCS(=O)(=O)N1CC=C(c2ccc3cc(O)c(N4CC(=O)NS4(=O)=O)c(F)c3c2)C1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5087544 |  |
IC50 | < | 1.0 | nM | 410.42 | O=C1CN(c2c(O)cc3ccc(OCC4CCCOC4)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5084380 |  |
IC50 | < | 1.0 | nM | 455.49 | CCS(=O)(=O)N1CC=C(c2ccc3cc(O)c(N4CC(=O)NS4(=O)=O)c(F)c3c2)C1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5075269 |  |
IC50 | < | 1.0 | nM | 416.38 | O=C1CN(c2c(O)cc3ccc(OCCC4CC4(F)F)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5030407 | single protein format |
| CHEMBL5415903 |  |
IC50 | = | 11.36 | nM | 375.18 | O=C1CN(c2c(O)cc3ccc(Br)cc3c2F)S(=O)(=O)N1 | Homo sapiens | CHEMBL5392766 | single protein format |
| CHEMBL253500 |  |
IC50 | = | 24.0 | nM | 596.71 | O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)c3ncc(CCCc4ccccc4)[nH]3)cc2)S(=O)(=O)N1 | Homo sapiens | CHEMBL927698 | single protein format |
| CHEMBL267759 |  |
IC50 | = | 24.0 | nM | 595.59 | O=P(O)(O)C(F)(F)c1ccc(CC(Cc2ccc(-c3ccccc3)cc2)(c2ccccc2)n2nnc3ccccc32)cc1 | Homo sapiens | CHEMBL805116 | cell-based format |
| CHEMBL248291 |  |
IC50 | = | 25.0 | nM | 524.62 | Cc1cc(C[C@H](NS(=O)(=O)c2ccccc2)c2nc3ccccc3[nH]2)ccc1[C@@H]1CC(=O)NS1(=O)=O | Homo sapiens | CHEMBL1071697 | single protein format |
| CHEMBL428589 |  |
IC50 | = | 38.0 | nM | 588.66 | O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)C3=NC[C@@H](Cc4ccccc4F)N3)cc2)S(=O)(=O)N1 | Homo sapiens | CHEMBL927698 | single protein format |
| CHEMBL436933 |  |
IC50 | = | 43.0 | nM | 578.59 | O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(C(F)(F)F)c3)c3nc4ccccc4[nH]3)cc2)S(=O)(=O)N1 | Homo sapiens | CHEMBL927698 | single protein format |
| CHEMBL416145 |  |
IC50 | = | 49.0 | nM | 545.53 | O=P(O)(O)C(F)(F)c1ccc(CC(C/C=C/c2ccccc2)(c2ccccc2)n2nnc3ccccc32)cc1 | Homo sapiens | CHEMBL805116 | cell-based format |
| CHEMBL403577 |  |
IC50 | = | 68.0 | nM | 584.7 | O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)C3=NC[C@@H](CCc4ccccc4)N3)cc2)S(=O)(=O)N1 | Homo sapiens | CHEMBL927698 | single protein format |
| CHEMBL9321 |  |
IC50 | = | 72.0 | nM | 547.54 | O=P(O)(O)C(F)(F)c1ccc(CC(CCCc2ccccc2)(c2ccccc2)n2nnc3ccccc32)cc1 | Homo sapiens | CHEMBL805116 | cell-based format |