P17655 | CAN2_HUMAN | Calpain-2 catalytic subunit (CAPN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00648 | Peptidase_C2 - Calpain family cysteine protease | 46~342 | |
| PF01067 | Calpain_III - Calpain large subunit, domain III | 362~502 | |
| PF13833 | EF-hand_8 - EF-hand domain pair | 545~603 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Calpain_III ]
[ Domain: "EF-hand" // EF-hand_8 ]
[ Domain: "EF-hand" // EF-hand_7_2 ]
[ Domain: "Cysteine proteinases" // Peptidase_C2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1921830 |  |
IC50 | = | 30.0 | nM | 523.63 | CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCCC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL36969 |  |
IC50 | = | 79.6 | nM | 518.61 | CCCCOc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C(=O)O)cc1 | Homo sapiens | CHEMBL658518 | single protein format |
| CHEMBL1921829 |  |
IC50 | = | 85.0 | nM | 509.6 | CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCCC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL36904 |  |
IC50 | = | 104.0 | nM | 476.53 | COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C(=O)O)cc1 | Homo sapiens | CHEMBL658518 | single protein format |
| CHEMBL36801 |  |
IC50 | = | 104.0 | nM | 446.5 | O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1 | Homo sapiens | CHEMBL658517 | single protein format |
| CHEMBL1921832 |  |
IC50 | = | 180.0 | nM | 537.66 | CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCCCC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL36146 |  |
IC50 | = | 184.0 | nM | 462.5 | O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1 | Homo sapiens | CHEMBL658518 | single protein format |
| CHEMBL177914 |  |
IC50 | = | 184.0 | nM | 446.5 | O=C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL658520 | single protein format |
| CHEMBL1921825 |  |
IC50 | = | 280.0 | nM | 533.62 | CC(C)[C@@H]1NC(=O)[C@@H](NS(=O)(=O)c2ccc(F)cc2)Cc2ccc(cc2)OCCCC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL1921834 |  |
IC50 | = | 295.0 | nM | 555.7 | CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCCCSC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL423112 |  |
IC50 | = | 350.0 | nM | 382.46 | CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(C=O)Cc1ccccc1 | Homo sapiens | CHEMBL1012294 | single protein format |
| CHEMBL1921831 |  |
IC50 | = | 700.0 | nM | 525.65 | CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCCC[C@@H](CO)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL1921827 |  |
IC50 | = | 850.0 | nM | 509.6 | CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)OCc2ccccc2)Cc2ccc(cc2)OCCC[C@@H](C=O)NC1=O | Homo sapiens | CHEMBL1924666 | single protein format |
| CHEMBL315636 |  |
Ki | = | 5.0 | nM | 404.49 | CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL658531 | single protein format |
| CHEMBL91991 |  |
Ki | = | 5.0 | nM | 510.61 | CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1 | Homo sapiens | CHEMBL658531 | single protein format |
| CHEMBL117023 |  |
Ki | = | 5.7 | nM | 440.5 | CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)O | Homo sapiens | CHEMBL658515 | single protein format |
| CHEMBL92114 |  |
Ki | = | 7.0 | nM | 420.56 | CS(=O)(=O)N[C@H](CSCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL658531 | single protein format |
| CHEMBL89766 |  |
Ki | = | 7.0 | nM | 418.52 | CC(OCc1ccccc1)[C@@H](NS(C)(=O)=O)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL658531 | single protein format |
| CHEMBL89008 |  |
Ki | = | 9.0 | nM | 418.52 | CCS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL658531 | single protein format |
| CHEMBL88895 |  |
Ki | = | 11.0 | nM | 380.49 | CS(=O)(=O)N[C@H](Cc1cccs1)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL658531 | single protein format |