P17405 | ASM_HUMAN | Sphingomyelin phosphodiesterase (SMPD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00149 | Metallophos - Calcineurin-like phosphoesterase | 202~462 | |
| PF19272 | ASMase_C - Acid sphingomyelin phosphodiesterase C-terminal region | 492~600 |
3D structures mapped by conservation among orthologs
[ Domain: "Saposin-like" // SapB_1 ]
[ Domain: "Metallo-dependent phosphatases" // PhoD_1 ]
[ Domain: "Metallo-dependent phosphatases" // PhoD_1,SapB_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4163007 |  |
IC50 | = | 20.0 | nM | 349.26 | CCCCCCCCCC(N)(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL4553570 |  |
IC50 | = | 20.0 | nM | 289.2 | CCCCCCCC(N)(P(=O)(O)O)P(=O)(O)O | Homo sapiens | CHEMBL4381550 | single protein format |
| CHEMBL4176817 |  |
IC50 | = | 70.0 | nM | 378.3 | CCCCCCCCCCCC(O)(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL4167088 |  |
IC50 | = | 290.0 | nM | 377.31 | CCCCCCCCCCCC(N)(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL4161092 |  |
IC50 | = | 300.0 | nM | 334.24 | CCCCCCCCCC(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL5434322 |  |
IC50 | = | 300.0 | nM | 345.74 | O=C(NO)c1noc(COc2ccc(-c3ccc(Cl)cc3)cc2)n1 | Homo sapiens | CHEMBL5382664 | single protein format |
| CHEMBL4172326 |  |
IC50 | = | 310.0 | nM | 348.27 | CCCCCCCCCCC(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL4551503 |  |
IC50 | = | 320.0 | nM | 344.75 | O=C(NO)c1cc(OCc2ccc(-c3ccc(Cl)cc3)cc2)no1 | Homo sapiens | CHEMBL4381524 | single protein format |
| CHEMBL4464117 |  |
IC50 | = | 340.0 | nM | 383.83 | COc1ccc(C(=O)NO)cc1OCc1ccc(-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL4381524 | single protein format |
| CHEMBL4169019 |  |
IC50 | = | 350.0 | nM | 306.19 | CCCCCCCC(OP(=O)(O)O)OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL4464068 |  |
IC50 | = | 360.0 | nM | 284.36 | CCCCCCCCCCOc1cc(C(=O)NO)on1 | Homo sapiens | CHEMBL4381524 | single protein format |
| CHEMBL4517596 |  |
IC50 | = | 360.0 | nM | 353.81 | O=C(NO)c1cccc(OCc2ccc(-c3ccc(Cl)cc3)cc2)c1 | Homo sapiens | CHEMBL4381549 | single protein format |
| CHEMBL4175277 |  |
IC50 | = | 440.0 | nM | 558.48 | CCCCCCCCCCCCS(=O)(=O)O[C@H]1OC(O)[C@H](OP(=O)(O)O)[C@@H](O)[C@@H]1OP(=O)(O)O | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL5409988 |  |
IC50 | = | 470.0 | nM | 345.74 | O=C(NO)c1nc(COc2ccc(-c3ccc(Cl)cc3)cc2)no1 | Homo sapiens | CHEMBL5382664 | single protein format |
| CHEMBL4167681 |  |
IC50 | = | 480.0 | nM | 323.43 | CCCCCCCCCCOc1cc(C(=O)NO)ccc1OC | Homo sapiens | CHEMBL4153026 | assay format |
| CHEMBL5413803 |  |
IC50 | = | 510.0 | nM | 315.72 | O=C(NO)c1nnc(-c2ccc(-c3ccc(Cl)cc3)cc2)o1 | Homo sapiens | CHEMBL5382664 | single protein format |
| CHEMBL5401959 |  |
IC50 | = | 810.0 | nM | 277.28 | CC(C)COc1ccc(-c2nnc(C(=O)NO)o2)cc1 | Homo sapiens | CHEMBL5382664 | single protein format |
| CHEMBL5416755 |  |
IC50 | = | 830.0 | nM | 311.3 | O=C(NO)c1nc(COc2ccc(-c3ccccc3)cc2)no1 | Homo sapiens | CHEMBL5382664 | single protein format |
| CHEMBL4471880 |  |
IC50 | = | 880.0 | nM | 310.31 | O=C(NO)c1cc(OCc2ccc(-c3ccccc3)cc2)no1 | Homo sapiens | CHEMBL4381524 | single protein format |
| CHEMBL5421810 |  |
IC50 | = | 1000.0 | nM | 276.29 | CCCCOc1ccc(-c2cc(C(=O)NO)no2)cc1 | Homo sapiens | CHEMBL5382664 | single protein format |