P17252 | KPCA_HUMAN | Protein kinase C alpha type (PRKCA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 341~583 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 37~87 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 102~153 | |
| PF00168 | C2 - C2 domain | 172~277 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 624~658 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // C2_2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Cysteine-rich domain" // C1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3970090 |  |
IC50 | = | 0.13 | nM | 542.57 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCC(F)(F)CC4)ncc3F)cnc2N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3957715 |  |
IC50 | = | 0.13 | nM | 429.49 | Nc1ncc(-c2cccc3[nH]ncc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3983009 |  |
IC50 | = | 0.13 | nM | 442.53 | Cn1ccc2c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(N)CC4)n3)cccc21 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3932204 |  |
IC50 | = | 0.13 | nM | 474.57 | Nc1ncc(-c2cccc(N3CCOCC3)c2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3895998 |  |
IC50 | = | 0.13 | nM | 407.45 | Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3963605 |  |
IC50 | = | 0.13 | nM | 389.46 | Nc1ncc(-c2ccccc2)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3958761 |  |
IC50 | = | 0.13 | nM | 555.57 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C4=CCOCC4)ncc3C(F)(F)F)cnc2N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3982497 |  |
IC50 | = | 0.13 | nM | 428.5 | Nc1ncc(-c2cccc3[nH]ccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3920517 |  |
IC50 | = | 0.13 | nM | 573.58 | Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3943147 |  |
IC50 | = | 0.13 | nM | 501.52 | CN(C)c1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(N)CC3)n2)n1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3980746 |  |
IC50 | = | 0.13 | nM | 542.57 | Nc1ncc(-c2cc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3951893 |  |
IC50 | = | 0.13 | nM | 496.5 | Nc1ncc(-c2cccc3[nH]c(C(F)(F)F)cc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3966595 |  |
IC50 | = | 0.13 | nM | 525.62 | Nc1ncc(-c2nc(N3CCOCC3)cc3ccccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3958917 |  |
IC50 | = | 0.13 | nM | 544.6 | Nc1ncc(-c2nc(N3CCOCC3)nc3ccc(F)cc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3966643 |  |
IC50 | = | 0.13 | nM | 543.55 | Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3892099 |  |
IC50 | = | 0.13 | nM | 539.64 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)cc4ccccc34)cnc2N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3969856 |  |
IC50 | = | 0.13 | nM | 442.53 | Cc1cc2c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(N)CC4)n3)cccc2[nH]1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3984009 |  |
IC50 | = | 0.13 | nM | 540.63 | CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)nc4ccccc34)cnc2N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3893533 |  |
IC50 | = | 0.13 | nM | 542.57 | Nc1ncc(-c2cc(N3CCOCC3)cc(C(F)(F)F)c2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |
| CHEMBL3984070 |  |
IC50 | = | 0.13 | nM | 544.54 | Nc1ncc(-c2nc(N3CCOCC3)ncc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 | Homo sapiens | CHEMBL3889158 | single protein format |