P16885 | PLCG2_HUMAN | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 | 532–617 | |
| PF00017 | SH2 | 646–720 | |
| PF00018 | SH3_1 | 775–821 | |
| PF00168 | C2 | 1062–1160 | |
| PF00387 | PI-PLC-Y | 930–1041 | |
| PF00388 | PI-PLC-X | 314–457 | |
| PF16457 | PH_12 | 56–129 | |
| PF23329 | EF_HAND_1_PLCG | 135–209 | |
| PF23583 | EF_HAND_2_PLCG | 235–305 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // PH ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5404368 |  |
IC50 | = | 11.05 | nM | 465.52 | C=CC(=O)N1CC[C@@H](N2N=C(Nc3ccc(Oc4ccccc4)cc3)c3c[nH]c4ncnc2c34)C1 | Homo sapiens | CHEMBL5355247 | cell-based format |
| CHEMBL509134 |  |
IC50 | = | 1000.0 | nM | 329.77 | Clc1cccc(-c2nc(-c3ccc(-c4ccon4)s3)no2)c1 | Homo sapiens | CHEMBL1018873 | cell-based format |
| CHEMBL475789 |  |
IC50 | = | 1000.0 | nM | 309.33 | O=C(NCCc1ccccc1)c1cc2cccc([N+](=O)[O-])c2[nH]1 | Homo sapiens | CHEMBL1018873 | cell-based format |
| CHEMBL475790 |  |
IC50 | = | 1000.0 | nM | 315.72 | O=C(Nc1ccc(Cl)cc1)c1cc2cccc([N+](=O)[O-])c2[nH]1 | Homo sapiens | CHEMBL1018873 | cell-based format |