P16591 | FER_HUMAN | Tyrosine-protein kinase Fer (FER)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 460~531 | |
| PF00611 | FCH - Fes/CIP4, and EFC/F-BAR homology domain | 11~85 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 565~814 |
3D structures mapped by conservation among orthologs
[ Domain: "SH2" // SH2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4461851 |  |
IC50 | = | 0.49 | nM | 389.46 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3cn[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL388978 |  |
IC50 | = | 1.8 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820486 | single protein format |
| CHEMBL3128069 |  |
IC50 | = | 2.0 | nM | 470.53 | Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 | Homo sapiens | CHEMBL3129261 | single protein format |
| CHEMBL4457164 |  |
IC50 | = | 2.6 | nM | 364.45 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)cc2C(N)=O)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4456804 |  |
IC50 | = | 2.7 | nM | 443.35 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Br)c3cn[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL3286830 |  |
IC50 | = | 3.3 | nM | 406.42 | C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 | Homo sapiens | CHEMBL3293403 | single protein format |
| CHEMBL4524587 |  |
IC50 | = | 4.7 | nM | 398.9 | Cc1cccc(Nc2nc(NC3CCCCC3N)c(Cl)c3cn[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4557212 |  |
IC50 | = | 10.0 | nM | 364.45 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3cn[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4455220 |  |
IC50 | = | 14.0 | nM | 364.45 | Cc1cccc(Nc2nc(NC3CCCCC3N)cc3cn[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4548027 |  |
IC50 | = | 25.0 | nM | 373.89 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Cl)cc2C(N)=O)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4564799 |  |
IC50 | = | 31.0 | nM | 363.47 | Cc1cccc(Nc2nc(NC3CCCCC3N)cc3cc[nH]c(=O)c23)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL3979920 |  |
IC50 | = | 51.0 | nM | 344.39 | Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 | Homo sapiens | CHEMBL3869729 | assay format |
| CHEMBL4470327 |  |
IC50 | = | 57.0 | nM | 364.45 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@H]3N)c(C#N)cc2C(N)=O)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL2064666 |  |
IC50 | = | 85.0 | nM | 539.08 | COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 | Homo sapiens | CHEMBL2067590 | single protein format |
| CHEMBL4475591 |  |
IC50 | = | 210.0 | nM | 365.48 | Cc1cccc(Nc2nc(NC3CCCCC3N)cc3c2C(=O)NCC3)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL3685796 |  |
IC50 | = | 232.0 | nM | 452.58 | Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 | Homo sapiens | CHEMBL4882592 | single protein format |
| CHEMBL4456510 |  |
IC50 | = | 410.0 | nM | 349.44 | Cc1cccc(Nc2nc(NC3CCCCC3)c(C#N)cc2C(N)=O)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4531557 |  |
IC50 | = | 440.0 | nM | 364.45 | Cc1cccc(Nc2nc(N[C@H]3CCCC[C@@H]3N)c(C#N)cc2C(N)=O)c1 | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4552333 |  |
IC50 | = | 440.0 | nM | 406.49 | CC(=O)N[C@H]1CCCC[C@H]1Nc1nc(Nc2cccc(C)c2)c(C(N)=O)cc1C#N | Homo sapiens | CHEMBL4305534 | assay format |
| CHEMBL4548125 |  |
IC50 | = | 460.0 | nM | 392.51 | Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)cc2C(=O)N(C)C)c1 | Homo sapiens | CHEMBL4305534 | assay format |