P16581 | LYAM2_HUMAN | E-selectin (SELE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF - EGF-like domain | 143~171 | |
| PF00059 | Lectin_C - Lectin C-type domain | 30~139 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 180~237 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 242~299 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 304~362 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 367~425 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 430~488 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 504~547 |
3D structures mapped by conservation among orthologs
[ Domain: "C-type lectin-like" // Lectin_C ]
[ Domain: "EGF/Laminin" // hEGF ]
[ Domain: "Complement control module/SCR domain" // Sushi ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL119501 |  |
IC50 | = | 0.7 | nM | 352.34 | CNC(=O)c1cc2c(Oc3ccc(C(F)(F)F)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL119733 |  |
IC50 | = | 1.0 | nM | 296.35 | C=Cc1ccc(Oc2cncc3sc(C(N)=O)cc23)cc1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL118113 |  |
IC50 | = | 2.0 | nM | 384.46 | NC(=O)c1cc2c(Oc3ccc(COC4CCCCO4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL325184 |  |
IC50 | = | 2.0 | nM | 350.4 | CNC(=O)c1cc2c(Oc3ccc(-n4ccnc4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL117198 |  |
IC50 | = | 3.0 | nM | 295.32 | N#Cc1ccc(Oc2cncc3sc(C(N)=O)cc23)cc1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL119039 |  |
IC50 | = | 4.0 | nM | 350.4 | CNC(=O)c1cc2c(Oc3ccc(-n4cccn4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL116070 |  |
IC50 | = | 4.0 | nM | 349.21 | NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL117746 |  |
IC50 | = | 5.0 | nM | 402.47 | COCCOCCOCc1ccc(Oc2cncc3sc(C(N)=O)cc23)cc1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL117894 |  |
IC50 | = | 5.0 | nM | 366.47 | CNC(=O)c1cc2c(Oc3ccc(-c4cccs4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL118034 |  |
IC50 | = | 5.0 | nM | 350.4 | CNC(=O)c1cc2c(Oc3ccc(-c4ccco4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL266198 |  |
IC50 | = | 5.0 | nM | 365.28 | NC(=O)c1cc2c(Sc3ccc(Br)cc3)cncc2s1 | Homo sapiens | CHEMBL803587 | cell-based format |
| CHEMBL117668 |  |
IC50 | = | 5.0 | nM | 358.42 | COCCOCc1ccc(Oc2cncc3sc(C(N)=O)cc23)cc1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL117279 |  |
IC50 | = | 6.0 | nM | 416.5 | CNC(=O)c1cc2c(Oc3ccc(COCCOCCOC)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL116152 |  |
IC50 | = | 6.0 | nM | 396.21 | NC(=O)c1cc2c(Oc3ccc(I)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL326120 |  |
IC50 | = | 6.0 | nM | 336.38 | NC(=O)c1cc2c(Oc3ccc(-n4ccnc4)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL118518 |  |
IC50 | = | 6.0 | nM | 304.76 | NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL326271 |  |
IC50 | = | 7.0 | nM | 363.24 | CNC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL331584 |  |
IC50 | = | 7.0 | nM | 372.45 | CNC(=O)c1cc2c(Oc3ccc(COCCOC)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL118886 |  |
IC50 | = | 8.0 | nM | 322.75 | NC(=O)c1cc2c(Oc3ccc(Cl)c(F)c3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |
| CHEMBL118074 |  |
IC50 | = | 8.0 | nM | 318.79 | CNC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 | Homo sapiens | CHEMBL802927 | cell-based format |