P16499 | PDE6A_HUMAN | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (PDE6A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 558~801 | |
| PF01590 | GAF - GAF domain | 76~216 | |
| PF01590 | GAF - GAF domain | 254~430 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL565305 |  |
IC50 | = | 4.7 | nM | 447.5 | CCCOCCn1c(=O)c(NCc2cnccn2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL584270 |  |
IC50 | = | 8.6 | nM | 439.52 | CCCOCCn1c(=O)c(NCC2CCCO2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL566797 |  |
IC50 | = | 9.3 | nM | 427.51 | CCCOCCn1c(=O)c(NCCOCC)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL567470 |  |
IC50 | = | 9.8 | nM | 453.54 | CCCOCCn1c(=O)c(N[C@H]2CC[C@H](O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL569481 |  |
IC50 | = | 10.8 | nM | 446.51 | CCCOCCn1c(=O)c(NCc2ccccn2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL551052 |  |
IC50 | = | 11.3 | nM | 468.56 | CCCOCCn1c(=O)c(NCCN2CCOCC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL567447 |  |
IC50 | = | 13.8 | nM | 413.48 | CCCOCCn1c(=O)c(NCCCO)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL585918 |  |
IC50 | = | 14.7 | nM | 495.58 | CCCOCCn1c(=O)c(NCC(=O)N2CCN(C)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL567471 |  |
IC50 | = | 15.1 | nM | 413.48 | CCCOCCn1c(=O)c(NC[C@@H](C)O)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL568839 |  |
IC50 | = | 15.2 | nM | 426.48 | CCCOCCn1c(=O)c(NCC(=O)NC)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL566820 |  |
IC50 | = | 15.3 | nM | 453.54 | CCCOCCn1c(=O)c(N[C@H]2CC[C@H](O)CC2)nc2ncc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL566367 |  |
IC50 | = | 15.3 | nM | 413.48 | CCCOCCn1c(=O)c(NC[C@H](C)O)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL565306 |  |
IC50 | = | 16.1 | nM | 482.54 | CCCOCCn1c(=O)c(NCC(=O)N2CCOCC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL569492 |  |
IC50 | = | 17.7 | nM | 413.48 | CCCOCCn1c(=O)c(N[C@H](C)CO)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL566375 |  |
IC50 | = | 17.9 | nM | 413.48 | CCCOCCn1c(=O)c(N[C@@H](C)CO)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL583854 |  |
IC50 | = | 23.2 | nM | 427.51 | CCCOCCn1c(=O)c(N[C@H](CC)CO)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL569045 |  |
IC50 | = | 23.6 | nM | 447.5 | CCCOCCn1c(=O)c(NCc2cnccn2)nc2ncc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL569264 |  |
IC50 | = | 24.6 | nM | 496.57 | CCCOCCn1c(=O)c(NCC(=O)N2CCC(O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL585327 |  |
IC50 | = | 26.3 | nM | 399.45 | CCCOCCn1c(=O)c(NCCO)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |
| CHEMBL567016 |  |
IC50 | = | 31.4 | nM | 453.54 | CCCOCCn1c(=O)c(NCC2CCOCC2)nc2ncc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042745 | single protein format |