P16473 | TSHR_HUMAN | Thyrotropin receptor (TSHR)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 | 431–678 | |
| PF13306 | LRR_5 | 61–127 | |
| PF13306 | LRR_5 | 164–221 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // LRR_8_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5281228 |  |
IC50 | = | 11.0 | nM | 480.53 | CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21 | Homo sapiens | CHEMBL5256362 | cell-based format |
| CHEMBL5275472 |  |
IC50 | = | 24.0 | nM | 424.49 | CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5267043 |  |
IC50 | = | 33.0 | nM | 476.45 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5287707 |  |
IC50 | = | 35.0 | nM | 476.96 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5267166 |  |
IC50 | = | 42.0 | nM | 440.97 | CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5288869 |  |
IC50 | = | 45.0 | nM | 374.49 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5270266 |  |
IC50 | = | 46.0 | nM | 408.5 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5286556 |  |
IC50 | = | 48.0 | nM | 438.52 | CC(=O)N1c2cnc(NC(=O)O[C@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5275619 |  |
IC50 | = | 49.0 | nM | 388.51 | CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5270771 |  |
IC50 | = | 56.0 | nM | 478.93 | CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5285685 |  |
IC50 | = | 58.0 | nM | 442.95 | CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5290721 |  |
IC50 | = | 62.0 | nM | 438.52 | CC(=O)N1c2cnc(NC(=O)O[C@@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5283477 |  |
IC50 | = | 65.0 | nM | 440.47 | CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5271120 |  |
IC50 | = | 71.0 | nM | 386.54 | CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5279687 |  |
IC50 | = | 72.0 | nM | 440.98 | CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5288635 |  |
IC50 | = | 74.0 | nM | 387.52 | CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5285143 |  |
IC50 | = | 82.0 | nM | 373.5 | CC(=O)N1c2cnc(NC(=O)OCC(C)C)cc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5285769 |  |
IC50 | = | 82.0 | nM | 407.51 | CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)cc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5268829 |  |
IC50 | = | 85.0 | nM | 410.47 | CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |
| CHEMBL5268512 |  |
IC50 | = | 91.0 | nM | 387.52 | CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C | Homo sapiens | CHEMBL5256331 | cell-based format |