P16455 | MGMT_HUMAN | Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01035 | DNA_binding_1 - 6-O-methylguanine DNA methyltransferase, DNA binding domain | 96~173 | |
| PF02870 | Methyltransf_1N - 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain | 7~82 |
3D structures mapped by conservation among orthologs
[ Domain: "Methylated DNA-protein cysteine methyltransferase-C" // DNA_binding_1 ]
[ Domain: "Methylated DNA-protein cysteine methyltransferase domain" // Methyltransf_1N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL337677 |  |
IC50 | = | 3.0 | nM | 233.26 | Nc1nc(Oc2cccs2)c2[nH]cnc2n1 | Homo sapiens | CHEMBL645820 | cell-based format |
| CHEMBL146769 |  |
IC50 | = | 5.0 | nM | 328.19 | NC1=NC(OCc2ccc(Br)s2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL485756 |  |
IC50 | = | 9.0 | nM | 270.3 | NCc1cccc(COc2nc(N)nc3nc[nH]c23)c1 | Homo sapiens | CHEMBL2176221 | cell-based format |
| CHEMBL339133 |  |
IC50 | = | 9.0 | nM | 326.18 | Nc1nc(OCc2cc(Br)cs2)c2[nH]cnc2n1 | Homo sapiens | CHEMBL712287 | cell-based format |
| CHEMBL151579 |  |
IC50 | = | 18.0 | nM | 249.3 | NC1=NC(OCc2cccs2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL2171205 |  |
IC50 | = | 25.0 | nM | 298.35 | CN(C)Cc1cccc(COc2nc(N)nc3[nH]cnc23)c1 | Homo sapiens | CHEMBL2176221 | cell-based format |
| CHEMBL345550 |  |
IC50 | = | 33.0 | nM | 250.29 | NC1=NC(OCc2cncs2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL333928 |  |
IC50 | = | 38.0 | nM | 242.24 | Nc1nc(OCc2ccccc2)c2[nH]nnc2n1 | Homo sapiens | CHEMBL712287 | cell-based format |
| CHEMBL151495 |  |
IC50 | = | 40.0 | nM | 278.7 | NC1=NC(OCc2ccnc(Cl)c2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL149722 |  |
IC50 | = | 51.0 | nM | 263.23 | Nc1nc(N)c(N=O)c(OCc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL752890 | single protein format |
| CHEMBL150324 |  |
IC50 | = | 70.0 | nM | 250.29 | NC1=NC(OCc2cnsc2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL146768 |  |
IC50 | = | 80.0 | nM | 233.23 | NC1=NC(OCc2ccco2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL2171202 |  |
IC50 | = | 86.0 | nM | 312.33 | CC(=O)NCc1cccc(COc2nc(N)nc3[nH]cnc23)c1 | Homo sapiens | CHEMBL2176221 | cell-based format |
| CHEMBL146734 |  |
IC50 | = | 130.0 | nM | 244.26 | NC1=NC(OCc2ccncc2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL71484 |  |
IC50 | = | 130.0 | nM | 245.24 | Nc1nc(N)c(N=O)c(OCc2ccccc2)n1 | Homo sapiens | CHEMBL752890 | single protein format |
| CHEMBL151785 |  |
IC50 | = | 200.0 | nM | 278.7 | NC1=NC(OCc2ccc(Cl)nc2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL150918 |  |
IC50 | = | 230.0 | nM | 288.27 | NC1=NC(OCc2cnc3c(c2)OCO3)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |
| CHEMBL358907 |  |
IC50 | = | 230.0 | nM | 246.23 | Nc1nc(N)c(N=O)c(OCc2ccncc2)n1 | Homo sapiens | CHEMBL752890 | single protein format |
| CHEMBL336215 |  |
IC50 | = | 250.0 | nM | 556.4 | Nc1nc(OCc2cc(Br)cs2)c2ncn(CC#CCO[C@H]3OC(CO)[C@@H](O)[C@@H](O)C3O)c2n1 | Homo sapiens | CHEMBL712287 | cell-based format |
| CHEMBL151552 |  |
IC50 | = | 250.0 | nM | 323.15 | NC1=NC(OCc2cncc(Br)c2)c2[nH]cnc2N1 | Homo sapiens | CHEMBL751006 | single protein format |