P16152 | CBR1_HUMAN | Carbonyl reductase [NADPH] 1 (CBR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00106 | adh_short - short chain dehydrogenase | 7~146 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // adh_short_C2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4640248 |  |
IC50 | = | 34.0 | nM | 314.73 | N=c1oc2c(O)cccc2cc1C(=O)Nc1ccccc1Cl | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL4640154 |  |
IC50 | = | 75.0 | nM | 348.28 | N=c1oc2c(O)cccc2cc1C(=O)Nc1ccccc1C(F)(F)F | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL4639417 |  |
IC50 | = | 120.0 | nM | 314.73 | N=c1oc2c(O)cccc2cc1C(=O)Nc1cccc(Cl)c1 | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL453375 |  |
IC50 | = | 210.0 | nM | 332.4 | C[C@H]1CCCC(=O)[C@@H](C)CC/C=C/c2cc(O)cc(O)c2C(=O)O1 | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL4646593 |  |
IC50 | = | 250.0 | nM | 308.34 | CCc1cccc(NC(=O)c2cc3cccc(O)c3oc2=N)c1 | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL4648793 |  |
IC50 | = | 270.0 | nM | 294.31 | Cc1ccc(NC(=O)c2cc3cccc(O)c3oc2=N)cc1 | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL4634960 |  |
IC50 | = | 370.0 | nM | 298.27 | N=c1oc2c(O)cccc2cc1C(=O)Nc1cccc(F)c1 | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL849 |  |
IC50 | = | 400.0 | nM | 289.55 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL4644092 |  |
IC50 | = | 440.0 | nM | 298.27 | N=c1oc2c(O)cccc2cc1C(=O)Nc1ccc(F)cc1 | Homo sapiens | CHEMBL4622626 | single protein format |
| CHEMBL117 |  |
IC50 | = | 670.0 | nM | 254.24 | O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL590508 |  |
IC50 | = | 788.0 | nM | 285.35 | CC(C)(C)N1NC(c2cccc(O)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL1068737 | single protein format |
| CHEMBL453375 | |
Ki | = | 40.0 | nM | 332.4 | C[C@H]1CCCC(=O)[C@@H](C)CC/C=C/c2cc(O)cc(O)c2C(=O)O1 | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL849 | |
Ki | = | 60.0 | nM | 289.55 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL117 | |
Ki | = | 110.0 | nM | 254.24 | O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL414883 |  |
Ki | = | 520.0 | nM | 364.78 | C[C@@H]1C[C@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 | Homo sapiens | CHEMBL1004505 | assay format |
| CHEMBL97453 |  |
Ki | = | 600.0 | nM | 314.25 | COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21 | Homo sapiens | CHEMBL1004505 | assay format |