P16118 | F261_HUMAN | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00300 | His_Phos_1 - Histidine phosphatase superfamily (branch 1) | 254~437 | |
| PF01591 | 6PF2K - 6-phosphofructo-2-kinase | 31~251 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // 6PF2K ]
[ Domain: "Phosphoglycerate mutase-like" // His_Phos_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3422678 |  |
IC50 | = | 191.0 | nM | 456.51 | Cc1noc(C)c1Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425138 | single protein format |
| CHEMBL3422677 |  |
IC50 | = | 294.0 | nM | 403.49 | CC(C)Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425138 | single protein format |
| CHEMBL3421735 |  |
IC50 | = | 321.0 | nM | 450.56 | CC(C)Cn1cc(C#N)c2cc(S(=O)(=O)c3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425138 | single protein format |
| CHEMBL3422674 |  |
IC50 | = | 701.0 | nM | 491.55 | CN1Cc2cc(-n3cc(C#N)c4cc(Oc5ccc(NC(=O)[C@@H]6CCCN6)cc5)ccc43)ccc2C1=O | Homo sapiens | CHEMBL3425138 | single protein format |