P16050 | LOX15_HUMAN | Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00305 | Lipoxygenase - Lipoxygenase | 210~643 | |
| PF01477 | PLAT - PLAT/LH2 domain | 4~102 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3604156 |  |
IC50 | = | 1.0 | nM | 352.98 | O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(Cl)c1Br | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL3604185 |  |
IC50 | = | 2.0 | nM | 288.52 | Clc1ccc2nc(-c3n[nH]c(Cl)c3Cl)oc2c1 | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL3604184 |  |
IC50 | = | 4.0 | nM | 254.08 | Clc1ccc2nc(-c3cc(Cl)[nH]n3)oc2c1 | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL1270608 |  |
IC50 | < | 10.0 | nM | 402.83 | O=C(OCC#CCSc1nnc(-c2ccc(Cl)cc2)o1)c1ccc(F)cc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1270220 |  |
IC50 | < | 10.0 | nM | 468.46 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1270113 |  |
IC50 | < | 10.0 | nM | 484.46 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1271220 |  |
IC50 | < | 10.0 | nM | 436.44 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1271116 |  |
IC50 | < | 10.0 | nM | 418.45 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cccc(F)c1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1271011 |  |
IC50 | < | 10.0 | nM | 400.46 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccccc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1270810 |  |
IC50 | < | 10.0 | nM | 456.55 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cc2ccccc2s1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1270314 |  |
IC50 | < | 10.0 | nM | 418.45 | O=C(OCC#CCSc1nnc(-c2ccc3ccccc3c2)o1)c1ccc(F)cc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL1270312 |  |
IC50 | < | 10.0 | nM | 406.49 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccsc1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL3290441 |  |
IC50 | = | 13.0 | nM | 500.64 | COc1cc(/C=C/c2cc(/C=C/c3cc(CC=C(C)C)c(O)c(OC)c3)[nH]n2)cc(CC=C(C)C)c1O | Homo sapiens | CHEMBL3295414 | cell-based format |
| CHEMBL3597768 |  |
IC50 | = | 17.0 | nM | 418.84 | O=C(Nc1ccc(F)cc1Cl)c1ccn(C(=S)Nc2ccc3c(c2)OCO3)n1 | Homo sapiens | CHEMBL3598540 | cell-based format |
| CHEMBL1270217 |  |
IC50 | = | 19.0 | nM | 406.49 | O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cccs1 | Homo sapiens | CHEMBL1273492 | single protein format |
| CHEMBL3604180 |  |
IC50 | = | 20.0 | nM | 219.63 | Clc1ccc2nc(-c3cc[nH]n3)oc2c1 | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL3604138 |  |
IC50 | = | 26.0 | nM | 222.63 | O=C(Nc1ccc(Cl)cn1)c1cc[nH]n1 | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL3604153 |  |
IC50 | = | 32.0 | nM | 308.53 | O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(Cl)c1Cl | Homo sapiens | CHEMBL3608050 | cell-based format |
| CHEMBL5089414 |  |
IC50 | = | 33.0 | nM | 473.6 | CCCCCCCCOC(=O)NS(=O)(=O)Nc1cc(-c2cc3ccccc3[nH]2)ccc1OC | Homo sapiens | CHEMBL5045044 | assay format |
| CHEMBL3604162 |  |
IC50 | = | 37.0 | nM | 342.08 | O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3608052 | cell-based format |