P15428 | PGDH_HUMAN | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00106 | adh_short - short chain dehydrogenase | 6~198 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // adh_short_C2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4060121 |  |
IC50 | = | 1.0 | nM | 414.58 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)nc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4072253 |  |
IC50 | = | 1.0 | nM | 336.51 | CCCC[S+]([O-])c1sc2nc(-c3cccs3)ccc2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4070789 |  |
IC50 | = | 1.3 | nM | 431.61 | CCCC[S@@+]([O-])c1sc2nc(-c3nccs3)cc(-c3cnc(C)n3C)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4070824 |  |
IC50 | = | 1.4 | nM | 413.59 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4097930 |  |
IC50 | = | 1.4 | nM | 397.53 | CCCC[S+]([O-])c1sc2nc(-c3ncco3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4091103 |  |
IC50 | = | 1.5 | nM | 412.61 | CCCC[S@@+]([O-])c1sc2nc(-c3cccs3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL5220078 |  |
IC50 | = | 1.6 | nM | 334.38 | Nc1ncc(-c2cnc3ccc(C(=O)N4CCCCC4)cc3n2)cn1 | Homo sapiens | CHEMBL5218029 | single protein format |
| CHEMBL5220207 |  |
IC50 | = | 1.7 | nM | 368.44 | O=C(c1ccc2ncc(-c3ccc4cnccc4c3)nc2c1)N1CCCCC1 | Homo sapiens | CHEMBL5218029 | single protein format |
| CHEMBL5219440 |  |
IC50 | = | 1.7 | nM | 362.39 | O=C(O)c1ccc(-c2cnc3ccc(C(=O)N4CCCCC4)cc3n2)cn1 | Homo sapiens | CHEMBL5218029 | single protein format |
| CHEMBL4071206 |  |
IC50 | = | 1.8 | nM | 420.61 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3nccs3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4065035 |  |
IC50 | = | 1.8 | nM | 433.58 | COCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3cnc(C)n3C)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4092806 |  |
IC50 | = | 1.8 | nM | 417.59 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3nccn3C)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4060870 |  |
IC50 | = | 1.9 | nM | 473.65 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3ccc(OCCO)cc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4076321 |  |
IC50 | = | 2.0 | nM | 457.65 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3cnc(C4CC4)n3C)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4076946 |  |
IC50 | = | 2.0 | nM | 394.54 | CCC[S+]([O-])c1sc2nc(-c3cccs3)cc(C(=O)OCC)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL5218684 |  |
IC50 | = | 2.0 | nM | 384.44 | O=C(c1ccc2ncc(-c3ccc4c(=O)[nH]ccc4c3)nc2c1)N1CCCCC1 | Homo sapiens | CHEMBL5218029 | single protein format |
| CHEMBL4082770 |  |
IC50 | = | 2.1 | nM | 513.71 | CCCC[S+]([O-])c1sc2nc(-c3nccs3)cc(-c3ccc(CNC(=O)NCC)cc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4087830 |  |
IC50 | = | 2.1 | nM | 398.58 | CCC[S+]([O-])c1sc2nc(-c3cccs3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4090222 |  |
IC50 | = | 2.1 | nM | 428.6 | COCCC[S+]([O-])c1sc2nc(-c3cccs3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |
| CHEMBL4061483 |  |
IC50 | = | 2.2 | nM | 412.61 | CCCC[S+]([O-])c1sc2nc(-c3cccs3)cc(-c3ccccc3)c2c1N | Homo sapiens | CHEMBL4051488 | assay format |