P15328 | FOLR1_HUMAN | Folate receptor alpha (FOLR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03024 | Folate_rec - Folate receptor family | 36~211 |
3D structures mapped by conservation among orthologs
[ Domain: "Frizzled cysteine-rich domain-related" // Folate_rec ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4445651 |  |
IC50 | = | 0.14 | nM | 465.46 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL1834488 |  |
IC50 | = | 0.31 | nM | 447.47 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3387471 | cell-based format |
| CHEMBL3628344 |  |
IC50 | = | 0.33 | nM | 447.47 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632252 | cell-based format |
| CHEMBL4790375 |  |
IC50 | = | 0.34 | nM | 464.53 | Nc1nc2sc(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4714598 | cell-based format |
| CHEMBL4465095 |  |
IC50 | = | 0.36 | nM | 479.49 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL4759798 |  |
IC50 | = | 0.44 | nM | 464.53 | Nc1nc2sc(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4714598 | cell-based format |
| CHEMBL4467936 |  |
IC50 | = | 0.51 | nM | 459.48 | Nc1nc2[nH]c(CCSc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432142 | cell-based format |
| CHEMBL4540298 |  |
IC50 | = | 0.58 | nM | 473.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL3628346 |  |
IC50 | = | 0.61 | nM | 447.47 | Nc1nc2[nH]c(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632252 | cell-based format |
| CHEMBL4557278 |  |
IC50 | = | 0.69 | nM | 474.45 | Nc1nc2[nH]c(CCCCc3cnc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL4783397 |  |
IC50 | = | 0.91 | nM | 478.55 | Nc1nc2sc(CCCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4714598 | cell-based format |
| CHEMBL4761741 |  |
IC50 | = | 1.08 | nM | 464.53 | Nc1nc2sc(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4714598 | cell-based format |
| CHEMBL4553188 |  |
IC50 | = | 1.08 | nM | 538.44 | Nc1nc2[nH]c(CCN(C(=O)C(F)(F)F)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432142 | cell-based format |
| CHEMBL4538151 |  |
IC50 | = | 1.12 | nM | 459.43 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL4214638 |  |
IC50 | = | 1.27 | nM | 456.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)nc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4194629 | cell-based format |
| CHEMBL4435608 |  |
IC50 | = | 1.4 | nM | 470.44 | CN(Cc1cc2c(=O)[nH]c(N)nc2[nH]1)C(=O)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4410581 | cell-based format |
| CHEMBL4441626 |  |
IC50 | = | 1.4 | nM | 473.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309285 | cell-based format |
| CHEMBL4562619 |  |
IC50 | = | 1.78 | nM | 470.44 | CN(Cc1cc2c(=O)[nH]c(N)nc2[nH]1)C(=O)c1cccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c1 | Homo sapiens | CHEMBL4410581 | cell-based format |
| CHEMBL590740 |  |
IC50 | = | 1.82 | nM | 461.5 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3412691 | cell-based format |
| CHEMBL4447805 |  |
IC50 | = | 1.89 | nM | 443.42 | Nc1nc2[nH]c(CCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432142 | cell-based format |