P15144 | AMPN_HUMAN | Aminopeptidase N (ANPEP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01433 | Peptidase_M1 - Peptidase family M1 domain | 316~543 | |
| PF11838 | ERAP1_C - ERAP1-like C-terminal domain | 619~945 | |
| PF17900 | Peptidase_M1_N - Peptidase M1 N-terminal domain | 81~279 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]
[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]
[ Domain: "ARM repeat" // ERAP1_C ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4854733 |  |
IC50 | = | 1.5 | nM | 527.6 | COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4822041 | single protein format |
| CHEMBL4877339 |  |
IC50 | = | 2.3 | nM | 513.58 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL4822041 | single protein format |
| CHEMBL3416733 |  |
IC50 | = | 3.7 | nM | 512.59 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL4822041 | single protein format |
| CHEMBL4853049 |  |
IC50 | = | 8.6 | nM | 469.57 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4822041 | single protein format |
| CHEMBL1159812 |  |
IC50 | = | 11.0 | nM | 151.3 | CSCCC(N)CS | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL1159811 |  |
IC50 | = | 20.0 | nM | 137.27 | CSCC(N)CS | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL1159809 |  |
IC50 | = | 20.0 | nM | 167.3 | C[S+]([O-])CCC(N)CS | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL4208547 |  |
IC50 | = | 20.0 | nM | 247.15 | CC1(C)OB(C(N)Cc2ccccc2)OC1(C)C | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL4216928 |  |
IC50 | = | 20.0 | nM | 130.98 | CC(C)CC(N)B(O)O | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL1159810 |  |
IC50 | = | 21.0 | nM | 153.27 | C[S+]([O-])CC(N)CS | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL4213478 |  |
IC50 | = | 25.0 | nM | 213.13 | CC(C)CC(N)B1OC(C)(C)C(C)(C)O1 | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL328470 |  |
IC50 | = | 28.0 | nM | 519.09 | CC(C)CN(CCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1)C(=O)CC(=O)NO | Homo sapiens | CHEMBL644741 | single protein format |
| CHEMBL414393 |  |
IC50 | = | 30.0 | nM | 167.28 | NC(CS)Cc1ccccc1 | Homo sapiens | CHEMBL646415 | single protein format |
| CHEMBL4204214 |  |
IC50 | = | 40.0 | nM | 171.05 | CC(N)B1OC(C)(C)C(C)(C)O1 | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL3764919 |  |
IC50 | = | 120.0 | nM | 293.37 | Cc1cccc(C)c1NC(=O)N[C@@H](CC(C)C)C(=O)NO | Homo sapiens | CHEMBL3767301 | cell-based format |
| CHEMBL4209822 |  |
IC50 | = | 190.0 | nM | 338.36 | CC(C)C[C@H](C(=O)N[C@H](C(=O)O)c1ccccc1)[C@H](O)C(=O)NO | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL4206158 |  |
IC50 | = | 220.0 | nM | 406.48 | CC(C)C[C@H](C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1)[C@H](O)C(=O)NO | Homo sapiens | CHEMBL4194794 | single protein format |
| CHEMBL4863168 |  |
IC50 | = | 230.0 | nM | 512.59 | CC(C)C[C@@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL4822041 | single protein format |
| CHEMBL226864 |  |
IC50 | = | 240.0 | nM | 319.34 | NC(Cc1ccccc1)P(=O)(O)C(O)CCc1ccccc1 | Homo sapiens | CHEMBL887382 | single protein format |
| CHEMBL3764432 |  |
IC50 | = | 280.0 | nM | 321.42 | CCc1cccc(CC)c1NC(=O)N[C@@H](CC(C)C)C(=O)NO | Homo sapiens | CHEMBL3767301 | cell-based format |