P15086 | CBPB1_HUMAN | Carboxypeptidase B (CPB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00246 | Peptidase_M14 - Zinc carboxypeptidase | 125~403 | |
| PF02244 | Propep_M14 - Carboxypeptidase activation peptide | 28~104 |
3D structures mapped by conservation among orthologs
[ Domain: "Protease propeptides/inhibitors" // Propep_M14 ]
[ Domain: "Zn-dependent exopeptidases" // Peptidase_M14 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL302054 |  |
IC50 | = | 1.0 | nM | 330.43 | Cc1cc(CC(C(=O)O)c2cn(CCCC(C)C)cn2)cnc1N | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL308195 |  |
IC50 | = | 1.0 | nM | 307.44 | CC(C)(C)CCn1cnc(C(C[C@H]2CC[C@H](N)C2)C(=O)O)c1 | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL66512 |  |
IC50 | = | 1.0 | nM | 316.41 | Cc1cc(CC(C(=O)O)c2cn(CCC(C)C)cn2)cnc1N | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL3577425 |  |
IC50 | = | 1.0 | nM | 478.68 | CC12CCC(C(NC(=O)[C@@H](CC3CCCCC3)NC(=O)N[C@@H](CCCCN)C(=O)O)C1)C2(C)C | Homo sapiens | CHEMBL3580150 | single protein format |
| CHEMBL3694281 |  |
IC50 | = | 3.0 | nM | 342.44 | CC1(C)CCC(n2cnc(C(Cc3ccc(N)nc3)C(=O)O)c2)CC1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL70177 |  |
IC50 | = | 4.0 | nM | 316.41 | CC(C)CCCn1cnc(C(Cc2ccc(N)nc2)C(=O)O)c1 | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL68399 |  |
IC50 | = | 4.0 | nM | 302.38 | CC(C)CCn1cnc(C(Cc2ccc(N)nc2)C(=O)O)c1 | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL3694275 |  |
IC50 | = | 11.0 | nM | 523.64 | Nc1ccc(CC(C(=O)O)c2cn(CC3CCCN(C(=O)C(c4ccccc4)c4ccccc4)C3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694273 |  |
IC50 | = | 12.0 | nM | 433.51 | Nc1ccc(CC(C(=O)O)c2cn(CC3CCCCN3C(=O)c3ccccc3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694272 |  |
IC50 | = | 12.0 | nM | 537.66 | Nc1ccc(CC(C(=O)O)c2cn(CCC3CCN(C(=O)C(c4ccccc4)c4ccccc4)CC3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694271 |  |
IC50 | = | 15.0 | nM | 442.48 | Nc1ccc(CC(C(=O)O)c2cn(-c3ccc(NC(=O)Nc4ccccc4)cc3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694267 |  |
IC50 | = | 16.0 | nM | 300.36 | Nc1ccc(CC(C(=O)O)c2cn(C3CCCC3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL303664 |  |
IC50 | = | 20.0 | nM | 246.27 | Cc1cc(CC(C(=O)O)c2c[nH]cn2)cnc1N | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL3694276 |  |
IC50 | = | 21.0 | nM | 475.59 | Nc1ccc(CC(C(=O)O)c2cn(CCC3CCN(C(=O)CCc4ccccc4)CC3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694270 |  |
IC50 | = | 23.0 | nM | 455.52 | Nc1ccc(CC(C(=O)O)c2cn(CC(=O)NC(c3ccccc3)c3ccccc3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694266 |  |
IC50 | = | 30.0 | nM | 314.39 | Nc1ccc(CC(C(=O)O)c2cn(C3CCCCC3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694274 |  |
IC50 | = | 38.0 | nM | 475.59 | Nc1ccc(CC(C(=O)O)c2cn(CCC3CCCN(C(=O)CCc4ccccc4)C3)cn2)cn1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL3694282 |  |
IC50 | = | 49.0 | nM | 408.46 | CCCNC(=O)Nc1ccc(-n2cnc(C(Cc3ccc(N)nc3)C(=O)O)c2)cc1 | Homo sapiens | CHEMBL3706209 | single protein format |
| CHEMBL302067 |  |
IC50 | = | 70.0 | nM | 232.24 | Nc1ccc(CC(C(=O)O)c2c[nH]cn2)cn1 | Homo sapiens | CHEMBL655448 | single protein format |
| CHEMBL302817 |  |
IC50 | = | 150.0 | nM | 251.33 | CCn1cnc(C(C[C@H]2CC[C@H](N)C2)C(=O)O)c1 | Homo sapiens | CHEMBL655448 | single protein format |