P14867 | GBRA1_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 43~250 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 257~341 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 372~439 |
3D structures mapped by conservation among orthologs
[ Domain: "Nicotinic receptor ligand binding domain-like" // Neur_chan_LBD ]
[ Domain: "Neurotransmitter-gated ion-channel transmembrane pore" // Neur_chan_memb ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1681887 |  |
IC50 | = | 1.0 | nM | 403.84 | Fc1ccccc1-n1nc2c(cnc3ccccc32)c1OCc1ccccc1Cl | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL20042 |  |
IC50 | = | 1.0 | nM | 295.73 | O=C1C2C=Nc3ccccc3C2=NN1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL3659674 |  |
IC50 | = | 1.2 | nM | 360.42 | COc1ncccc1-c1cc(-n2cnc3cc(C(C)(C)O)ccc32)ccn1 | Homo sapiens | CHEMBL3705279 | single protein format |
| CHEMBL2008708 |  |
IC50 | = | 2.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 | Homo sapiens | CHEMBL5235582 | single protein format |
| CHEMBL5281056 |  |
IC50 | = | 3.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 | Homo sapiens | CHEMBL5235582 | single protein format |
| CHEMBL3659676 |  |
IC50 | = | 7.5 | nM | 348.38 | CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2ccncc2F)c1 | Homo sapiens | CHEMBL3705279 | single protein format |
| CHEMBL911 |  |
IC50 | = | 14.0 | nM | 307.4 | Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1 | Homo sapiens | CHEMBL676828 | tissue-based format |
| CHEMBL3659677 |  |
IC50 | = | 26.0 | nM | 355.4 | CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2ccncc2C#N)c1 | Homo sapiens | CHEMBL3705279 | single protein format |
| CHEMBL1270841 |  |
IC50 | = | 34.0 | nM | 316.36 | CC(OC(=O)c1cc2c(cn1)[nH]c1ccccc12)c1ccccc1 | Homo sapiens | CHEMBL5235573 | single protein format |
| CHEMBL3659675 |  |
IC50 | = | 38.0 | nM | 364.84 | CC(C)(O)c1ccc2c(c1)ncn2-c1ccnc(-c2cccnc2Cl)c1 | Homo sapiens | CHEMBL3705279 | single protein format |
| CHEMBL1681889 |  |
IC50 | = | 46.0 | nM | 424.33 | Clc1ccc(-n2nc3c4c(ncc3c2OCc2ccccc2Cl)CCCC4)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681897 |  |
IC50 | = | 50.0 | nM | 407.88 | Fc1ccc(COc2c3cnc4c(c3nn2-c2ccc(Cl)cc2)CCCC4)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681888 |  |
IC50 | = | 50.0 | nM | 429.86 | Clc1ccccc1COc1c2cnc3ccccc3c2nn1-c1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681895 |  |
IC50 | = | 64.0 | nM | 407.88 | Fc1ccccc1COc1c2cnc3c(c2nn1-c1ccc(Cl)cc1)CCCC3 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681886 |  |
IC50 | = | 64.0 | nM | 420.3 | Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCc2ccccc2Cl)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681892 |  |
IC50 | = | 67.0 | nM | 452.39 | CC1(C)CCc2ncc3c(OCc4ccccc4Cl)n(-c4ccc(Cl)cc4)nc3c2C1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681885 |  |
IC50 | = | 74.0 | nM | 349.82 | Clc1ccc(-n2nc3c(cnc4ccccc43)c2OCC2CC2)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681900 |  |
IC50 | = | 94.0 | nM | 353.85 | Clc1ccc(-n2nc3c4c(ncc3c2OCC2CC2)CCCC4)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL1681899 |  |
IC50 | = | 134.0 | nM | 415.88 | Clc1ccc(-n2nc3c(cnc4ccc(-n5ccnc5)cc43)c2OCC2CC2)cc1 | Homo sapiens | CHEMBL1687497 | cell-based format |
| CHEMBL3586473 |  |
IC50 | = | 150.0 | nM | 488.91 | COc1cccc(F)c1C1=NCc2cnc(Nc3ccc(C(=O)O)cc3)nc2-c2ccc(Cl)cc21 | Homo sapiens | CHEMBL3586973 | single protein format |