P14735 | IDE_HUMAN | Insulin-degrading enzyme (IDE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00675 | Peptidase_M16 - Insulinase (Peptidase family M16) | 74~212 | |
| PF05193 | Peptidase_M16_C - Peptidase M16 inactive domain | 238~416 | |
| PF16187 | Peptidase_M16_M - Middle or third domain of peptidase_M16 | 422~702 | |
| PF22456 | PqqF-like_C_4 - PQQ synthase PqqF-like, C-terminal lobe domain 4 | 810~908 |
3D structures mapped by conservation among orthologs
[ Domain: "LuxS/MPP-like metallohydrolase" // Peptidase_M16_M_C ]
[ Domain: "LuxS/MPP-like metallohydrolase" // Peptidase_M16_M_N ]
[ Domain: "LuxS/MPP-like metallohydrolase" // Peptidase_M16_C_2 ]
[ Domain: "LuxS/MPP-like metallohydrolase" // Peptidase_M16 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL51085 |  |
IC50 | = | 42.0 | nM | 274.18 | O=c1c2ccccc2[se]n1-c1ccccc1 | Homo sapiens | CHEMBL4399071 | cell-based format |
| CHEMBL4241044 |  |
IC50 | = | 56.0 | nM | 447.47 | O=C(C[C@@H](Cc1ccc2ccccc2c1)n1cc(CNC(=O)c2ccc(F)cc2)nn1)NO | Homo sapiens | CHEMBL4232680 | single protein format |
| CHEMBL4527561 |  |
IC50 | = | 56.0 | nM | 449.49 | O=C(C[C@@H](Cc1ccc2ccccc2c1)N1C=C(CNC(=O)c2ccc(F)cc2)NN1)NO | Homo sapiens | CHEMBL4357319 | single protein format |
| CHEMBL3235416 |  |
IC50 | = | 100.0 | nM | 401.47 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(CCCc1ccccc1)CC(=O)O | Homo sapiens | CHEMBL3243737 | single protein format |
| CHEMBL3235414 |  |
IC50 | = | 600.0 | nM | 402.45 | COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(CCCc1ccccc1)CC(=O)O | Homo sapiens | CHEMBL3243737 | single protein format |
| CHEMBL3235415 |  |
IC50 | = | 600.0 | nM | 373.41 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(CC(=O)O)Cc1ccccc1 | Homo sapiens | CHEMBL3243737 | single protein format |