P14679 | TYRO_HUMAN | Tyrosinase (TYR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00264 | Tyrosinase - Common central domain of tyrosinase | 172~402 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL463145 |  |
IC50 | = | 23.0 | nM | 286.24 | O=c1cc(-c2ccc(O)cc2O)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL4136573 | single protein format |
| CHEMBL24152 |  |
IC50 | = | 60.0 | nM | 457.39 | O=C(N[C@@H](Cc1ccccc1)C(=O)OCc1cc(=O)c(O)co1)OCc1cc(=O)c(O)co1 | Homo sapiens | CHEMBL813551 | single protein format |
| CHEMBL394855 |  |
IC50 | = | 70.0 | nM | 272.26 | O=C(/C=C/c1ccc(O)cc1O)c1ccc(O)cc1O | Homo sapiens | CHEMBL4411347 | single protein format |
| CHEMBL465880 |  |
IC50 | = | 80.0 | nM | 340.38 | CC(C)=CCc1c(O)ccc(C(=O)/C=C/c2ccc(O)cc2O)c1O | Homo sapiens | CHEMBL4411347 | single protein format |
| CHEMBL480477 |  |
IC50 | = | 90.0 | nM | 324.38 | CC1(C)C=Cc2c(ccc3c2OC[C@@H](c2ccc(O)cc2O)C3)O1 | Homo sapiens | CHEMBL4053414 | single protein format |
| CHEMBL43065 |  |
IC50 | = | 90.0 | nM | 244.25 | Oc1cc(O)cc(/C=C/c2ccc(O)cc2O)c1 | Homo sapiens | CHEMBL4723116 | cell-based format |
| CHEMBL1563332 |  |
IC50 | = | 154.0 | nM | 370.45 | COc1cc2c(c(OC)c1CC=C(C)C)C[C@H](c1ccc(O)cc1O)CO2 | Homo sapiens | CHEMBL3810649 | single protein format |
| CHEMBL4239110 |  |
IC50 | = | 170.0 | nM | 356.37 | C/C(=C\Cc1c(O)ccc(C(=O)/C=C/c2ccc(O)cc2O)c1O)CO | Homo sapiens | CHEMBL4411347 | single protein format |
| CHEMBL1630857 |  |
IC50 | = | 177.0 | nM | 356.42 | COc1c(CC=C(C)C)c(O)cc2c1C[C@H](c1ccc(O)cc1O)CO2 | Homo sapiens | CHEMBL3810649 | single protein format |
| CHEMBL499124 |  |
IC50 | = | 370.0 | nM | 246.26 | Oc1ccc(CCc2ccc(O)cc2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL491410 |  |
IC50 | = | 430.0 | nM | 378.38 | Oc1ccc(CCc2ccc(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)cc2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL443605 |  |
IC50 | = | 560.0 | nM | 194.27 | CCCCCCc1ccc(O)cc1O | Homo sapiens | CHEMBL3619576 | single protein format |
| CHEMBL1760463 |  |
IC50 | = | 680.0 | nM | 570.54 | OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL1794031 |  |
IC50 | = | 700.0 | nM | 423.37 | CC[C@H](C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1 | Homo sapiens | CHEMBL813551 | single protein format |
| CHEMBL489989 |  |
IC50 | = | 730.0 | nM | 510.49 | Oc1ccc(CCc2ccc(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)cc2O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c(O)c1 | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL1760462 |  |
IC50 | = | 770.0 | nM | 408.4 | OC[C@H]1O[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL1760464 |  |
IC50 | = | 830.0 | nM | 570.54 | OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1764166 | single protein format |
| CHEMBL4743159 |  |
IC50 | = | 900.0 | nM | 278.33 | CC(C)C(=O)Nc1nc(-c2ccc(O)cc2O)cs1 | Homo sapiens | CHEMBL5331164 | cell-based format |
| CHEMBL458395 |  |
IC50 | = | 980.0 | nM | 288.25 | O=C1C[C@@H](c2ccc(O)cc2O)Oc2cc(O)cc(O)c21 | Homo sapiens | CHEMBL4411347 | single protein format |
| CHEMBL150 |  |
IC50 | = | 1000.0 | nM | 286.24 | O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL3810649 | single protein format |