P14625 | ENPL_HUMAN | Endoplasmin (HSP90B1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00183 | HSP90 - Hsp90 protein | 257~773 | |
| PF13589 | HATPase_c_3 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 101~221 |
3D structures mapped by conservation among orthologs
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1214827 |  |
IC50 | = | 22.0 | nM | 409.53 | CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O | Homo sapiens | CHEMBL4707003 | single protein format |
| CHEMBL200102 |  |
IC50 | = | 26.0 | nM | 512.38 | CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21 | Homo sapiens | CHEMBL3427924 | single protein format |
| CHEMBL3426787 |  |
IC50 | = | 32.0 | nM | 386.84 | COC(=O)c1c(O)cc(O)c(Cl)c1CCc1nccn1Cc1ccccc1 | Homo sapiens | CHEMBL3626591 | cell-based format |
| CHEMBL2103879 |  |
IC50 | = | 37.7 | nM | 364.41 | CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4647894 |  |
IC50 | = | 49.42 | nM | 464.57 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCCCC2)cc1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4744238 |  |
IC50 | = | 50.0 | nM | 313.36 | Cc1ncc2c(n1)CN(C(=O)c1cc(C(C)C)c(O)cc1O)C2 | Homo sapiens | CHEMBL4707003 | single protein format |
| CHEMBL4647171 |  |
IC50 | = | 54.1 | nM | 445.5 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(S(C)(=O)=O)c1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4635982 |  |
IC50 | = | 77.96 | nM | 425.44 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc2c(c1)OCCO2 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4641526 |  |
IC50 | = | 78.01 | nM | 463.56 | CC(C)c1cc(-c2nnn(Cc3ccccc3)c2-c2ccc(S(C)(=O)=O)cc2)c(O)cc1O | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL252164 |  |
IC50 | = | 85.0 | nM | 465.55 | CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1 | Homo sapiens | CHEMBL1100284 | single protein format |
| CHEMBL4639163 |  |
IC50 | = | 88.98 | nM | 445.5 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4635778 |  |
IC50 | = | 96.2 | nM | 459.52 | CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(S(C)(=O)=O)c1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4648197 |  |
IC50 | = | 100.46 | nM | 459.52 | CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL3426784 |  |
IC50 | = | 101.0 | nM | 511.39 | CC(C)NCCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)nccc21 | Homo sapiens | CHEMBL3427924 | single protein format |
| CHEMBL365118 |  |
IC50 | = | 120.0 | nM | 378.29 | C#CCCCn1c(Sc2ccc(Cl)cc2Cl)nc2c(N)ncnc21 | Homo sapiens | CHEMBL3427924 | single protein format |
| CHEMBL192480 |  |
IC50 | = | 170.0 | nM | 412.73 | C#CCCCn1c(Sc2cc(Cl)c(Cl)cc2Cl)nc2c(N)ncnc21 | Homo sapiens | CHEMBL3427924 | single protein format |
| CHEMBL4648091 |  |
IC50 | = | 174.8 | nM | 454.53 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(OCCN(C)C)cc1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4638275 |  |
IC50 | = | 190.22 | nM | 460.51 | COC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1cccc(NS(C)(=O)=O)c1 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4641450 |  |
IC50 | = | 192.09 | nM | 439.47 | CCOC(=O)Cn1nnc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc2c(c1)OCCO2 | Homo sapiens | CHEMBL4614281 | single protein format |
| CHEMBL4869481 |  |
IC50 | = | 194.0 | nM | 398.6 | Nc1nc(Cl)c2nc(O)n(Cc3cc4c(cc3Br)OCO4)c2n1 | Homo sapiens | CHEMBL4824941 | single protein format |