P14618 | KPYM_HUMAN | Pyruvate kinase PKM (PKM)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00224 | PK - Pyruvate kinase, barrel domain | 43~375 | |
| PF02887 | PK_C - Pyruvate kinase, alpha/beta domain | 410~528 |
3D structures mapped by conservation among orthologs
[ Domain: "PK beta-barrel domain-like" // PK_2nd ]
[ Domain: "TIM barrels" // PK_1st ]
[ Domain: "PK C-terminal domain-like" // PK_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5396216 |  |
IC50 | = | 16.0 | nM | 571.69 | CCN1CCC(CN(C(=O)[C@@H]2CCN(Cc3ccccc3)C2)c2ccc([As]3SCCS3)cc2)CC1 | Homo sapiens | CHEMBL5381492 | cell-based format |
| CHEMBL5399474 |  |
IC50 | = | 122.0 | nM | 513.51 | CCN1CCC(CN(C(=O)[C@@H]2CCN(Cc3ccccc3)C2)c2ccc([As](O)O)cc2)CC1 | Homo sapiens | CHEMBL5381472 | single protein format |
| CHEMBL5404355 |  |
IC50 | = | 139.0 | nM | 312.2 | CN1CC[C@@H](C(=O)Nc2ccc([As](O)O)cc2)C1 | Homo sapiens | CHEMBL5381472 | single protein format |
| CHEMBL5440683 |  |
IC50 | = | 285.0 | nM | 402.33 | CN1CC[C@@H](C(=O)N(Cc2ccccc2)c2ccc([As](O)O)cc2)C1 | Homo sapiens | CHEMBL5381472 | single protein format |
| CHEMBL5400237 |  |
IC50 | = | 326.0 | nM | 478.42 | O=C([C@@H]1CCN(Cc2ccccc2)C1)N(Cc1ccccc1)c1ccc([As](O)O)cc1 | Homo sapiens | CHEMBL5381472 | single protein format |
| CHEMBL9470 |  |
IC50 | = | 500.0 | nM | 288.3 | CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O | Homo sapiens | CHEMBL4182153 | assay format |
| CHEMBL3609603 |  |
IC50 | = | 650.0 | nM | 596.54 | C[C@@H]1O[C@@H](O[C@H]2[C@H](Oc3cc(O)c4c(c3)O[C@H](c3ccc(O)c(O)c3)CC4=O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL5137789 | single protein format |
| CHEMBL5412106 |  |
IC50 | = | 671.0 | nM | 513.51 | CCN1CCC(CN(C(=O)[C@H]2CCN(Cc3ccccc3)C2)c2ccc([As](O)O)cc2)CC1 | Homo sapiens | CHEMBL5381472 | single protein format |
| CHEMBL129451 |  |
IC50 | = | 850.0 | nM | 442.38 | O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@H]1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL5137788 | single protein format |
| CHEMBL126142 |  |
IC50 | = | 850.0 | nM | 442.38 | O=C(O[C@H]1Cc2c(O)cc(O)cc2O[C@H]1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL5223207 | single protein format |
| CHEMBL4281402 |  |
IC50 | = | 880.0 | nM | 504.77 | O=C1C(CSC(=S)N2CCCCC2)=C(CSC(=S)N2CCCCC2)C(=O)c2ccccc21 | Homo sapiens | CHEMBL4259022 | assay format |
| CHEMBL28457 |  |
IC50 | = | 900.0 | nM | 288.3 | CC(C)=CC[C@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O | Homo sapiens | CHEMBL5137735 | single protein format |
| CHEMBL31574 |  |
IC50 | = | 900.0 | nM | 286.24 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 | Homo sapiens | CHEMBL5137791 | single protein format |
| CHEMBL28 |  |
IC50 | = | 990.0 | nM | 270.24 | O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL5137747 | single protein format |