P14555 | PA2GA_HUMAN | Phospholipase A2, membrane associated (PLA2G2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00068 | Phospholip_A2_1 - Phospholipase A2 | 22~130 |
3D structures mapped by conservation among orthologs
[ Domain: "Phospholipase A2, PLA2" // Phospholip_A2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL436456 |  |
IC50 | = | 4.0 | nM | 470.53 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1Cc1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL356606 |  |
IC50 | = | 6.0 | nM | 456.5 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL357979 |  |
IC50 | = | 6.0 | nM | 442.47 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL347957 |  |
IC50 | = | 6.0 | nM | 468.51 | NC(=O)C(=O)c1c(C2CC2)n(Cc2ccccc2-c2ccccc2)c2cccc(OCC(=O)O)c12 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL345488 |  |
IC50 | = | 6.0 | nM | 435.26 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL180576 |  |
IC50 | = | 7.0 | nM | 559.64 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3c(c2n1Cc1ccccc1)CCCC3 | Homo sapiens | CHEMBL829138 | single protein format |
| CHEMBL5177527 |  |
IC50 | = | 7.0 | nM | 466.5 | Cc1c(C(=O)C(N)=O)c2c(OCn3cnnn3)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL5150979 | single protein format |
| CHEMBL345986 |  |
IC50 | = | 7.0 | nM | 414.85 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL433701 |  |
IC50 | = | 8.0 | nM | 388.46 | CCCCCCCCn1c(C)c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc21 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL347748 |  |
IC50 | = | 8.0 | nM | 378.43 | CCc1c(C(=O)C(N)=O)c2c(CC(=O)O)cc(C)cc2n1Cc1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL5172164 |  |
IC50 | = | 8.0 | nM | 442.47 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL5150979 | single protein format |
| CHEMBL148674 |  |
IC50 | = | 9.0 | nM | 380.4 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL355944 |  |
IC50 | = | 9.0 | nM | 442.47 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL148795 |  |
IC50 | = | 9.0 | nM | 400.82 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1Cl | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL179118 |  |
IC50 | = | 9.0 | nM | 424.43 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3c(c2n1Cc1ccccc1F)CCC3 | Homo sapiens | CHEMBL829138 | single protein format |
| CHEMBL357804 |  |
IC50 | = | 9.0 | nM | 416.43 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1cccc2ccccc12 | Homo sapiens | CHEMBL761440 | single protein format |
| CHEMBL179966 |  |
IC50 | = | 10.0 | nM | 424.43 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3c(c2n1Cc1cccc(F)c1)CCC3 | Homo sapiens | CHEMBL829138 | single protein format |
| CHEMBL423762 |  |
IC50 | = | 10.0 | nM | 450.47 | Cc1c(CC(N)=O)c2c(OCC(=O)[O-])cccc2n1Cc1ccccc1-c1ccccc1.[Na+] | Homo sapiens | CHEMBL761443 | single protein format |
| CHEMBL361552 |  |
IC50 | = | 10.0 | nM | 406.44 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3c(c2n1Cc1ccccc1)CCC3 | Homo sapiens | CHEMBL829138 | single protein format |
| CHEMBL422667 |  |
IC50 | = | 10.0 | nM | 380.4 | Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL761440 | single protein format |