P14416 | DRD2_HUMAN | D(2) dopamine receptor (DRD2)

Pfam Domain Table

AccessionDomainRangeColor
PF000017tm_1 - 7 transmembrane receptor (rhodopsin family)51~426

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL567 IC50 = 0.3 nM 403.98 OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 Homo sapiens CHEMBL2390217 cell-based format
CHEMBL3885419 IC50 = 1.1 nM 361.53 CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1 Homo sapiens CHEMBL3876354 cell-based format
CHEMBL8514 IC50 = 1.1 nM 361.53 CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1 Homo sapiens CHEMBL3779713 cell-based format
CHEMBL267930 IC50 = 1.27 nM 395.48 O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1 Homo sapiens CHEMBL2060922 cell-based format
CHEMBL726 IC50 = 1.616 nM 437.53 OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL2028019 IC50 = 1.7 nM 427.42 CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1 Homo sapiens CHEMBL3293231 cell-based format
CHEMBL4128926 IC50 = 1.8 nM 583.78 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 Homo sapiens CHEMBL4121476 single protein format
CHEMBL8809 IC50 = 1.83 nM 347.24 CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC Homo sapiens CHEMBL4345338 cell-based format
CHEMBL1403281 IC50 = 1.95 nM 575.71 CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL1202213 IC50 = 2.0 nM 442.23 Br.Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1Cl Homo sapiens CHEMBL671074 single protein format
CHEMBL1201192 IC50 = 2.1 nM 273.36 NC(=O)C[S@@+]([O-])C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL3863997 cell-based format
CHEMBL1108 IC50 = 2.407 nM 379.44 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL219916 IC50 = 2.647 nM 425.92 O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL157138 IC50 = 2.86 nM 338.46 CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL2392349 IC50 = 3.5 nM 443.59 COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 Homo sapiens CHEMBL2395897 cell-based format
CHEMBL3287403 IC50 = 3.8 nM 462.38 O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 Homo sapiens CHEMBL3293231 cell-based format
CHEMBL3299097 IC50 = 3.98 nM 391.56 COc1ccccc1N1CCN(CCCCCCNC(=O)OC(C)(C)C)CC1 Homo sapiens CHEMBL3300164 cell-based format
CHEMBL54 IC50 = 4.0 nM 375.87 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 Homo sapiens CHEMBL671074 single protein format
CHEMBL1909072 IC50 = 4.05 nM 401.96 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 Homo sapiens CHEMBL1909140 cell membrane format
CHEMBL3306803 IC50 = 4.1 nM 393.51 CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 Homo sapiens CHEMBL4710573 single protein format