P14410 | SUIS_HUMAN | Sucrase-isomaltase, intestinal (SI)

Pfam Domain Table

AccessionDomainRangeColor
PF00088Trefoil - Trefoil (P-type) domain70~108
PF00088Trefoil - Trefoil (P-type) domain936~977
PF01055Glyco_hydro_31_2nd - Glycosyl hydrolases family 31 TIM-barrel domain345~702
PF01055Glyco_hydro_31_2nd - Glycosyl hydrolases family 31 TIM-barrel domain1216~1596
PF13802Gal_mutarotas_2 - Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain141~303
PF13802Gal_mutarotas_2 - Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain1010~1173
PF21365Glyco_hydro_31_3rd - Glycosyl hydrolase family 31 C-terminal domain710~797
PF21365Glyco_hydro_31_3rd - Glycosyl hydrolase family 31 C-terminal domain1604~1691

3D structures mapped by conservation among orthologs

[ Domain: "Glycosyl hydrolase domain" // Glyco_hydro_31_C ]

 PyMOL session

[ Domain: "supersandwich" // Gal_mutarotas_2 ]

 PyMOL session

[ Domain: "Putative glucosidase YicI, C-terminal domain" // DUF5110_1 ]

 PyMOL session

[ Domain: "TIM barrels" // Glyco_hydro_31_N ]

 PyMOL session

[ Domain: "Trefoil/Plexin domain-like" // Trefoil ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3349437 IC50 = 2.3 nM 297.35 OC[C@@]1(O)C[C@H](NCCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2374254 IC50 = 2.9 nM 313.35 OC[C@@]1(O)C[C@H](NC[C@H](O)c2ccccc2)[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349441 IC50 = 3.3 nM 289.35 OC[C@@]1(O)C[C@H](NCc2cccs2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349431 IC50 = 4.6 nM 253.25 OCN(CO)[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349432 IC50 = 5.2 nM 291.34 OC[C@@]1(O)C[C@H](N[C@@H]2CCCC[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2374253 IC50 = 6.6 nM 313.35 OC[C@H](N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1 Homo sapiens CHEMBL808823 single protein format
CHEMBL3349442 IC50 = 6.8 nM 411.54 CC(C)(C)c1cc(CN[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)cc(C(C)(C)C)c1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2051761 IC50 = 7.5 nM 336.39 C[C@H]1C[C@H](N)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349433 IC50 = 9.3 nM 289.37 OC[C@@]1(O)C[C@H](NCC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2051983 IC50 = 10.0 nM 353.37 CO[C@H]1O[C@H](C)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349438 IC50 = 11.0 nM 329.44 CC(C)=CCC/C(C)=C/CN[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349443 IC50 = 14.0 nM 309.36 OC[C@@]1(O)C[C@H](NC/C=C/c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349435 IC50 = 15.0 nM 362.22 OC[C@@]1(O)C[C@H](NCc2ccc(Br)cc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349446 IC50 = 15.0 nM 284.31 OC[C@@]1(O)C[C@H](NCc2cccnc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349434 IC50 = 15.0 nM 275.35 OC[C@@]1(O)C[C@H](NC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2051982 IC50 = 35.0 nM 337.37 C[C@H]1C[C@@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2051762 IC50 = 36.0 nM 337.37 C[C@H]1C[C@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL222396 IC50 = 49.0 nM 193.2 N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL2051981 IC50 = 80.0 nM 369.37 CO[C@H]1O[C@H](CO)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O Homo sapiens CHEMBL808823 single protein format
CHEMBL3349439 IC50 = 160.0 nM 291.34 OC[C@@]1(O)C[C@H](N[C@H]2CCCC[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL808823 single protein format