P14222 | PERF_HUMAN | Perforin-1 (PRF1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 416~497 | |
| PF01823 | MACPF - MAC/Perforin domain | 154~367 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3754633 |  |
IC50 | = | 180.0 | nM | 335.38 | NC(=O)c1ccc(-c2ccc(-c3ccc4c(c3)COC4=O)s2)cc1 | Homo sapiens | CHEMBL3756437 | cell-based format |
| CHEMBL1934375 |  |
IC50 | = | 340.0 | nM | 343.39 | O=C1NC(=S)N/C1=C/c1csc(-c2ccc3c(c2)COC3=O)n1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL1934383 |  |
IC50 | = | 360.0 | nM | 375.41 | O=C1NC(=S)N/C1=C/c1cc2ccc(-c3ccc4c(c3)COC4=O)cc2[nH]1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL1934381 |  |
IC50 | = | 360.0 | nM | 392.46 | O=C1NC(=S)N/C1=C/c1cc2ccc(-c3ccc4c(c3)COC4=O)cc2s1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL1934370 |  |
IC50 | = | 370.0 | nM | 337.36 | O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)COC3=O)cn1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL1934397 |  |
IC50 | = | 400.0 | nM | 370.41 | O=C1NC(=S)NC(=O)C1=Cc1ccc(-c2ccc3c(c2)COC3=O)s1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL3103651 |  |
IC50 | = | 400.0 | nM | 325.35 | O=C1NC(=O)/C(=C\c2ccc(-c3ccc4c(c3)CNC4=O)s2)N1 | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL1934386 |  |
IC50 | = | 470.0 | nM | 387.42 | O=C1NC(=S)N/C1=C/c1ccc2cc(-c3ccc4c(c3)COC4=O)ccc2n1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL1934380 |  |
IC50 | = | 490.0 | nM | 392.46 | O=C1NC(=S)N/C1=C/c1cc2cc(-c3ccc4c(c3)COC4=O)ccc2s1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL3103907 |  |
IC50 | = | 510.0 | nM | 355.44 | CN1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL1934382 |  |
IC50 | = | 510.0 | nM | 376.39 | O=C1NC(=S)N/C1=C/c1cc2cc(-c3ccc4c(c3)COC4=O)ccc2o1 | Homo sapiens | CHEMBL1936847 | cell-based format |
| CHEMBL3103914 |  |
IC50 | = | 530.0 | nM | 399.5 | O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)CN(CCCO)C3=O)s1 | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL3103917 |  |
IC50 | = | 550.0 | nM | 413.48 | CCOC(=O)N1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL3103908 |  |
IC50 | = | 600.0 | nM | 369.47 | CCN1Cc2cc(-c3ccc(/C=C4/NC(=S)NC4=O)s3)ccc2C1=O | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL3103655 |  |
IC50 | = | 630.0 | nM | 336.38 | O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)CNC3=O)cn1 | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL3103647 |  |
IC50 | = | 640.0 | nM | 355.44 | O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)C(=O)NCC3)s1 | Homo sapiens | CHEMBL3106784 | cell-based format |
| CHEMBL3754407 |  |
IC50 | = | 670.0 | nM | 351.38 | NC(=O)c1ccc(-c2ccc(-c3ccc4c(c3)COC4=O)s2)cc1O | Homo sapiens | CHEMBL3756437 | cell-based format |
| CHEMBL4169732 |  |
IC50 | = | 750.0 | nM | 505.58 | CN1Cc2cc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccc(C(=O)O)cc5)c4)s3)ccc2C1=O | Homo sapiens | CHEMBL4130818 | cell-based format |
| CHEMBL4453871 |  |
IC50 | = | 780.0 | nM | 560.58 | COc1ncc(-c2ccc(-c3cnc4c(c3)CN(C)C4=O)s2)cc1NS(=O)(=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL4343116 | cell-based format |
| CHEMBL1934364 |  |
IC50 | = | 780.0 | nM | 342.4 | O=C1NC(=S)N/C1=C/c1ccc(-c2ccc3c(c2)COC3=O)s1 | Homo sapiens | CHEMBL1936847 | cell-based format |