P14091 | CATE_HUMAN | Cathepsin E (CTSE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00026 | Asp - Eukaryotic aspartyl protease | 77~394 | |
| PF07966 | A1_Propeptide - A1 Propeptide | 23~49 |
3D structures mapped by conservation among orthologs
[ Domain: "acid protease" // Asp_C ]
[ Domain: "acid protease" // Asp_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL595066 |  |
IC50 | = | 0.4 | nM | 571.76 | COCc1cc2cc(c1)C(=O)N[C@H]([C@H](O)CNC1(c3cccc(C(C)C)c3)CC1)Cc1cccc(c1)OCCCCN2 | Homo sapiens | CHEMBL1050391 | single protein format |
| CHEMBL600326 |  |
IC50 | = | 4.0 | nM | 543.71 | Cc1cc2cc(n1)OCCCCOc1cccc(c1)C[C@@H]([C@H](O)CNC1(c3cccc(C(C)C)c3)CC1)NC2=O | Homo sapiens | CHEMBL1050391 | single protein format |
| CHEMBL595267 |  |
IC50 | = | 5.0 | nM | 573.73 | COCc1cc2cc(n1)OCCCCOc1cccc(c1)C[C@@H]([C@H](O)CNC1(c3cccc(C(C)C)c3)CC1)NC2=O | Homo sapiens | CHEMBL1050391 | single protein format |
| CHEMBL589369 |  |
IC50 | = | 8.0 | nM | 517.67 | Cc1cc2cc(n1)OCCCCOc1cccc(c1)C[C@@H]([C@H](O)CNCc1cccc(C(C)C)c1)NC2=O | Homo sapiens | CHEMBL1050391 | single protein format |
| CHEMBL588662 |  |
IC50 | = | 99.0 | nM | 383.5 | CCC(CN1C(=N)NC(c2ccccc2)(c2ccccc2)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888553 | single protein format |
| CHEMBL3109548 |  |
IC50 | = | 233.0 | nM | 494.59 | COc1ccc(C2(c3ccc(OC)cc3)NC(=N)N(C3CCN(C(=O)OC(C)(C)C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL3888553 | single protein format |
| CHEMBL3354688 |  |
IC50 | = | 320.0 | nM | 416.48 | CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 | Homo sapiens | CHEMBL3371641 | single protein format |
| CHEMBL3109544 |  |
IC50 | = | 511.0 | nM | 395.46 | COc1ccc(C2(c3ccc(OC)cc3)NC(=N)N(C3CCOCC3)C2=O)cc1 | Homo sapiens | CHEMBL3888553 | single protein format |
| CHEMBL3109550 |  |
IC50 | = | 841.0 | nM | 409.49 | COc1ccc(C2(c3ccc(OC)cc3)NC(=N)N(CC3CCOCC3)C2=O)cc1 | Homo sapiens | CHEMBL3888553 | single protein format |
| CHEMBL403727 |  |
Ki | = | 24.0 | nM | 593.72 | CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)c1 | Homo sapiens | CHEMBL929077 | single protein format |
| CHEMBL166175 |  |
Ki | = | 90.0 | nM | 574.81 | CCC(C)[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(C)C)C(=O)NCc1ccccn1 | Homo sapiens | CHEMBL661023 | single protein format |